Embracing the Unknown

Researchers are showing that ambiguity can be essential to brain development.

Written byJamie Holmes
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

CROWN, OCTOBER 2015Scholars have sliced and diced the terms “ambiguity,” “uncertainty,” and “ignorance,” among others, in a variety of different ways. Oftentimes, the usefulness of these sharp lines isn’t plainly apparent. But one dividing line between types of unknowns that has recently led researchers to fascinating new biological insights is the distinction between risk and ambiguity. According to decision theorists, risky choices are those where the specific outcome isn’t known while the odds of success are. Think of flipping a coin. You’re certain of the probability of its landing on heads or tails, but you can’t predict the outcome of any particular toss. Ambiguous choices are those whose odds of success are unknown because the rules determining the outcome are unclear.

This important distinction between ambiguity and risk is one that I explore in my book, Nonsense: The Power of Not Knowing.

Economic theorist Daniel Ellsberg’s famous thought experiment illustrates the contrast. Say you have to pick out a ball from one of two urns, both containing black and red balls. Each urn contains one hundred balls. Pull out a red ball, and you’ll win a hundred dollars. Pick a black one, and you’ll get zilch. But the two urns are different. Urn 1 holds anywhere from zero to one hundred red balls and from zero to one hundred black ones. Urn 2 has fifty black balls and fifty red balls. Ellsberg realized that if you ask people whether they’d prefer to bet on pulling from ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina

Products

nuclera logo

Nuclera eProtein Discovery System installed at leading Universities in Taiwan

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo