Two genes have been found to down-regulate the non-homologous end-joining pathway in meiotic diploid yeast cells.
The DNA-repair mechanism referred to as non-homologous end-joining (NHEJ) involves the Ku proteins (Ku70 and Ku80), DNA ligase IV and Lif1/XRCC4. Meiotic cells down-regulate NHEJ, to favour homologous recombination. In the December 6
They found that
Valencia et al. suggest that NEJ1 affects the cellular localization of LIF1 during meoisis. It will be interesting to see whether similar regulation of NHEJ components occurs during ...
The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.
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