- Gordon Tomkins to Julius Axelrod, circa 1950
Courtesy of International Union of Biochemistry and Molecular Biology
A portion of the 22nd edition of Sigma-Aldrich's Metabolic Pathways map which was designed by Donald E. Nicholson at the University of Leeds. The enzymes are indicated by IUBMB Commission numbers. For example, in the top, left-hand corner [above UDP] is 2.4.99.7, which is a sialyltransferase.
Today's researchers rarely resort to razor blades to understand how enzymes function. Investigators can capture the kinetics of a single enzyme molecule or use site-directed mutagenesis and crystallography to appreciate the subtleties of enzymatic action.
Such technological advances help enzymologists understand the fundamental biological processes that have an impact on life sciences as diverse as systems biology, neurology, and ecology. Modern enzymology also has numerous commercial applications, ...
