FDA Chastises Doctor for Promoting 3-Parent IVF

The illegal in vitro fertilization technique helps couples eliminate mitochondrial defects in embryos by combining genes from three people: a mother, father, and a donor egg.

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Zhang with a baby boy born to a Jordanian couple using 3-Parent IVF NEW HOPE FERTILITY CLINICThe US Food and Drug Administration condemned New York fertility doctor John Zhang for promoting a controversial procedure that combines DNA from an egg donor with DNA from a mother and father—dubbed the three-person or three-parent baby technique—CNN reports. In a letter last week (August 4), the FDA asks Zhang to detail how he plans to resolve the situation.

The procedure, which can help parents elude genetic disorders, was successfully used on a Jordanian couple who wanted a child without passing on the mother’s fatal neurological disorder. The couple gave birth to a baby boy a year ago.

Zhang’s company and fertility clinic keep marketing the procedure despite previously pledging to refrain from conducting it in the U.S., the Associated Press reports. His start-up company, Darwin Life, also touts the technique—described as spindle nuclear transfer—as a means to help older women get pregnant, reports MIT Technology Review.

The procedure entails removing the bulk of the donor egg’s genetic material and replacing it with the mother’s chromosomes. The donor’s mitochondrial DNA still remains. Once fertilized, the modified embryo contains three individuals’ genetic contributions.

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