Previous work by Leonard Guarente and colleagues at the Department of Biology, Massachusetts Institute of Technology demonstrated that adding an extra copy of the
Tissenbaum and Guarente surveyed the lifespan of
The lifespan extension mediated by sir-2.1 was suppressed by a deletion in the daf-16 gene, indicating that sir-2.1 acts through daf-16. The daf-16 gene encodes a transcription factor believed to promote stress resistance and longevity in adult worms. In larvae, the activated daf-16 gene product promotes ...