Advances in medicine will undoubtedly be linked to our ability to correlate human genetic variation with disease. In the 23 May ScienceXpress, Stacey Gabriel and colleagues report a large-scale analysis of haplotypes in the human genome (Sciencexpress 2002, DOI:10.1126/science.1069424).Gabriel et al. characterized haplotype patterns for 51 genomic regions with an average size of 250 kb (covering 13 megabases) from African, European and Asian DNA samples. They genotyped thousands of single nucleo
Advances in medicine will undoubtedly be linked to our ability to correlate human genetic variation with disease. In the 23 May
Gabriel
The striking similarity in SNP polymorphisms, recombination sites and haplotypes supports the 'Out of Africa' model for human history. The existence of extensive haplotype blocks will greatly facilitate the study of human variation.
This study provides the foundations for construction of a haplotype map of ...
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