The human
Heterochromatin interactions
The human AF10 gene has been associated with chromosomal translocation in acute leukemias. In the March 15 EMBO Reports, Linder et al. describe their study of the Drosophila AF10 homolog, dAF10, in an attempt to understand its function (EMBO Reports 2001, 2:211-216). They isolated the dAF10 gene from a database screen and show that it codes for four transcripts that are differentially expressed during fly embryogenesis. The dAF10 protein contains a PLVVL pentamer motif that mediates interaction

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Jonathan Weitzman
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