Skip to main content

How Toxic is the World’s Most Popular Herbicide Roundup?

Glyphosate, the active ingredient in Roundup, is designed to be toxic to plants, but scientists observe some untoward effects on animals in the lab. 

Written byKatarina Zimmer
| 9 min read

Register for free to listen to this article
Listen with Speechify
0:00
9:00

ISTOCK, NARONGCPGlyphosate, the active ingredient in the world’s most widely used herbicide, Roundup, is arguably also one of the most contentious. Mass protests erupted in Europe last November after the European Commission, following much discussion, granted a five-year extension for the license to use glyphosate in agriculture in the E.U.

Farmers have relied upon glyphosate-based herbicides to kill unwanted vegetation for more than four decades, but its use sparked hefty debate in 2015, when the World Health Organization’s International Agency for Research on Cancer (IARC) concluded that it was “probably carcinogenic,” adding it to a category that also contains red meat, for instance. This followed previous conclusions by research agencies such as the European Food Safety Authority (EFSA) and the U.S. Environmental Protection Agency (EPA) that glyphosate is unlikely to pose a cancer risk to humans.

There’s no question that the research around this small molecule has become highly politicized. Environmental activists have claimed that exposure is linked to everything from cancer to celiac disease to autism, while on the other hand, industry-backed reviews have ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

  • katya katarina zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field of science and wanted to write about all of them. Following an internship with The Scientist in 2017, she’s been happily freelancing for a number of publications, covering everything from climate change to oncology. Katarina is a news correspondent for The Scientist and contributes occasional features to the magazine. Find her on Twitter @katarinazimmer and read her work on her website.

    View Full Profile

Related Topics

Related articles background image
August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

View this Issue
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi
Mapping Clonal Mosaicism in Aging Tissues

Mapping Clonal Mosaicism in Aging Tissues

Mission bio

Products

Sino Biological Logo

Sino Biological Launches SuperNuclease ® Pro with Free Trial Program

Sino Biological Logo

Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

Lucid Scientific logo
Conceptual image of ice and frost.

The VAULT100 PRO: Inside the most advanced Stirling Ultracold ULT freezer ever built.

Stirling Ultracold logo