How Toxic is the World’s Most Popular Herbicide Roundup?

Glyphosate, the active ingredient in Roundup, is designed to be toxic to plants, but scientists observe some untoward effects on animals in the lab.

katya katarina zimmer
| 9 min read

Register for free to listen to this article
Listen with Speechify
0:00
9:00
Share

ISTOCK, NARONGCPGlyphosate, the active ingredient in the world’s most widely used herbicide, Roundup, is arguably also one of the most contentious. Mass protests erupted in Europe last November after the European Commission, following much discussion, granted a five-year extension for the license to use glyphosate in agriculture in the E.U.

Farmers have relied upon glyphosate-based herbicides to kill unwanted vegetation for more than four decades, but its use sparked hefty debate in 2015, when the World Health Organization’s International Agency for Research on Cancer (IARC) concluded that it was “probably carcinogenic,” adding it to a category that also contains red meat, for instance. This followed previous conclusions by research agencies such as the European Food Safety Authority (EFSA) and the U.S. Environmental Protection Agency (EPA) that glyphosate is unlikely to pose a cancer risk to humans.

There’s no question that the research around this small molecule has become highly politicized. Environmental activists have claimed that exposure is linked to everything from cancer to celiac disease to autism, while on the other hand, industry-backed reviews have ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • katya katarina zimmer

    Katarina Zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field. Following an internship with The Scientist in 2017, she has been happily freelancing for a number of publications, covering everything from climate change to oncology.
Share
May digest 2025 cover
May 2025, Issue 1

Study Confirms Safety of Genetically Modified T Cells

A long-term study of nearly 800 patients demonstrated a strong safety profile for T cells engineered with viral vectors.

View this Issue
iStock

TaqMan Probe & Assays: Unveil What's Possible Together

Thermo Fisher Logo
Meet Aunty and Tackle Protein Stability Questions in Research and Development

Meet Aunty and Tackle Protein Stability Questions in Research and Development

Unchained Labs
Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Detecting Residual Cell Line-Derived DNA with Droplet Digital PCR

Bio-Rad
How technology makes PCR instruments easier to use.

Making Real-Time PCR More Straightforward

Thermo Fisher Logo

Products

fujirebio-square-logo

Fujirebio Receives Marketing Clearance for Lumipulse® G pTau 217/ β-Amyloid 1-42 Plasma Ratio In-Vitro Diagnostic Test

The Scientist Placeholder Image

Biotium Launches New Phalloidin Conjugates with Extended F-actin Staining Stability for Greater Imaging Flexibility

Leica Microsystems Logo

Latest AI software simplifies image analysis and speeds up insights for scientists

BioSkryb Genomics Logo

BioSkryb Genomics and Tecan introduce a single-cell multiomics workflow for sequencing-ready libraries in under ten hours