Human Genome Project: Is `Big Science' Bad For Biology?

In the physical sciences, there seems to be little if any disagreement over what constitutes big science. Few physicists, for example, would disagree that the Superconducting Supercollider and the space station Freedom are both big science projects--that is, they both involve many scientists clustered at a single facility as opposed to individual researchers or small groups working independently in labs around the country. In the life sciences, however, consensus on this issue is rare. Biomedi

Written byJulia King
| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

In the life sciences, however, consensus on this issue is rare. Biomedical researchers have yet to reach a majority opinion on whether the human genome project (HGP) should or should not be classified as a big science project. Moreover, some life scientists object to the very concept of big and small biology projects. As University of Utah biochemist Martin Rechsteiner wrote in a letter to FASEB Journal (4:2941-2, 1990), "The words conjure up big leagues versus little leagues, serious versus trivial, important versus unimportant."

Yet interestingly enough, disagreement over how the HGP should be labeled has not stopped supporters and opponents of the massive genetic program from advancing their causes with some of the same arguments that inevitably crop up during debates on the topic of big science versus little science. Among those on either side of the project are biochemist Bernard Davis and molecular biologist Leroy Hood, who both ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Meet the Author

Published In

Share
December digest cover image of a wooden sculpture comprised of multiple wooden neurons that form a seahorse.
December 2025, Issue 1

Wooden Neurons: An Artistic Vision of the Brain

A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.

View this Issue
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Merck
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

MilliporeSigma purple logo
Abstract wireframe sphere with colorful dots and connecting lines representing the complex cellular and molecular interactions within the tumor microenvironment.

Exploring the Inflammatory Tumor Microenvironment 

Cellecta logo
An image of a DNA sequencing spectrum with a radial blur filter applied.

A Comprehensive Guide to Next-Generation Sequencing

Integra Logo

Products

brandtech logo

BRANDTECH® Scientific Announces Strategic Partnership with Copia Scientific to Strengthen Sales and Service of the BRAND® Liquid Handling Station (LHS) 

Top Innovations 2026 Contest Image

Enter Our 2026 Top Innovations Contest

Biotium Logo

Biotium Expands Tyramide Signal Amplification Portfolio with Brighter and More Stable Dyes for Enhanced Spatial Imaging

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS