Reprinted with permission from Nature
PROTEIN SILENCING: Silencing of nuclear envelope proteins lamin A/C siRNA duplex (a,d) with GL2 luciferase siRNA duplex (nonspecific siRNA control) (b), and with buffer only (c). Staining with lamin A/C specific antibody (a,c); staining with NuMA-specific antibody (d).

Data derived from the Science Watch/Hot Papers database and the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age.

S.M. Elbashir et al., "RNA interference is mediated by 21- and 22-nucleotide RNAs," Genes Devel, 15:188-200, Jan. 15, 2001. (Cited in 158 papers)

S.M. Elbashir et al., "Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells," Nature, 411:494-8, May 24, 2001. (Cited in 276 papers)

Scientists once thought of eukaryotic RNA as solely active in transcription as messenger RNA (mRNA), and in translation as transfer RNA (tRNA). After...

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