Learning Enhances Synapses Between “Memory Cells” in Mice

A new technique reveals certain neuronal connections grow larger and denser when memories are made.

Written byDiana Kwon
| 3 min read

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ISTOCK, D-KEINE

When making memories, certain neurons form larger, denser connections, according to a study published today (April 26) in Science.

Scientists have long attempted to understand where, and how, the brain stores memories. At the beginning of the 20th century, German scientist Richard Semon coined the term “engram” to describe the hypothetical physical representations of memories in the brain. Then, in the 1940s, Canadian psychologist Donald Hebb proposed that, when neurons encoded memories, connections, called synapses, between coactivated memory, or engram, cells were strengthened—a theory that was famously paraphrased as neurons that “fire together, wire together.” These two ideas have become the cornerstone of memory research—and in the decades since they first emerged, scientists have amassed evidence supporting them.

“Donald Hebb suggested that it’s not engram ...

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  • Diana is a freelance science journalist who covers the life sciences, health, and academic life. She’s a regular contributor to The Scientist and her work has appeared in several other publications, including Scientific American, Knowable, and Quanta. Diana was a former intern at The Scientist and she holds a master’s degree in neuroscience from McGill University. She’s currently based in Berlin, Germany.

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