Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

synaptic plasticity
Giannina Descalzi
Giannina Descalzi Studies the Factors Underlying Chronic Pain
Natalia Mesa | May 16, 2022
The University of Guelph neuroscientist is scoping out the brain regions and genes that change as a consequence of pain that lasts for months or even years.
An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left). Scale bar 50 µm.
Amyloid Precursor Protein Linked to Brain Development Mechanisms
Catherine Offord | Dec 1, 2021
Researchers provide evidence that the Alzheimer’s-associated protein calibrates a signaling pathway that is conserved across the animal kingdom.
panel depicting mossy fiber synapses and glutamate signaling dynamics
Infographic: Reverse Signaling Between Neurons
Christie Wilcox | Jun 4, 2021
So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.
artistic representation of a neuron synapse with light and dark dots passing between two axons
Hippocampal Cell Communication Is Bidirectional: Study
Christie Wilcox | Jun 4, 2021
In an unexpected twist in neuroscience dogma, the cells on the receiving end of neurotransmission appear to be able to release glutamate to regulate the transmitting cell’s activity.
Flexible Synapse Strength May Underpin Mammal Brain’s Complexity
Asher Jones | Mar 24, 2021
Neural connections in the mouse neocortex can release multiple packages of neurotransmitters per electrical impulse, a study finds.
Infographic: A New Model of Synapse Strength
Asher Jones | Mar 24, 2021
Synapses in the mouse neocortex can release multiple packages of neurotransmitters, suggesting that connection strength is more flexible than previously thought.
The World Within
Bob Grant | Feb 1, 2019
Internalizing the environment might be the next step in humans’ relationship with our planet.
“Minibrains” May Soon Include Neanderthal DNA
Ashley Yeager | May 14, 2018
Brain organoids engineered to carry the genetic material could reveal how our brains are similar to and different from those of our closest relatives.
RNA Moves a Memory From One Snail to Another
Ashley Yeager | May 14, 2018
Injecting molecules from a sea slug that received tail shocks into one that didn’t made the recipient animal behave more cautiously. 
Learning Enhances Synapses Between “Memory Cells” in Mice
Diana Kwon | Apr 26, 2018
A new technique reveals certain neuronal connections grow larger and denser when memories are made.
Image of the Day: Fountain of Youth
The Scientist Staff | Aug 14, 2017
Neural plasticity wanes with age, but increasing the protein Arc—abundant earlier in life—in the visual cortex of mice can fend off this decline.
A Potential Remedy for the Aging Brain
Aggie Mika | Aug 8, 2017
In mice, injected fragments of a naturally occurring protein boost memory in young and old animals and improve cognition and mobility in a model of neurodegenerative disease. 
Memories Erased from Snail Neurons
Diana Kwon | Jun 28, 2017
Scientists block particular enzymes to remove the cellular signatures associated with specific memory types.  
Profile: Dean Buonomano Studies How the Brain Encodes Time
Anna Azvolinsky | Sep 1, 2016
The UCLA neurobiologist uses computational modeling, in vitro electrophysiology, and human psychophysics experiments to explore how neurons and the brain as a whole perceive and respond to time.
What Lies Sleeping
Philippe Mourrain | Mar 1, 2016
Why can science still not define this most basic biological process?
Lost Memories Reactivated in Mice
Kerry Grens | May 29, 2015
Using optogenetics, researchers excite selected neurons to reinstate a fear memory that had been blocked.
Rhythmic Rewiring
Jyoti Madhusoodanan | Nov 1, 2014
Circadian neurons in fruit flies form synapses with different, noncircadian brain regions depending on the time of day.
Schizophrenia’s Intricacies
Abby Olena | Jan 23, 2014
Two studies provide insight into the genetics of the disorder and show again how complex it is.
Mice Learn Faster with Human Glia
Dan Cossins | Mar 7, 2013
Mice with human brain cells showed enhanced synaptic plasticity and learning, suggesting glia may be key to our cognitive prowess.