Cell Cycle
Cell Cycle
Edited by: Eugene Russo C. Deng, P. Zhang, J.W. Harper, S.J. Elledge, P. Leder, "Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control," Cell, 82, 675-84, 1995. (Cited in more than 170 papers through June 1997) Comments by Philip Leder, Harvard Medical School The gene p21CIP1/WAF1 inhibits the proper functioning of cyclin-dependent kinases (CDKs), molecules that help to control cellular duplication. Although p21CIP1/WAF1 is known to be regulated by