HOTPAPERS
HOTPAPERS
B. Vogelstein, E.R. Fearon, S.R. Hamilton, S.E. Kern, et al., “Genetic alterations during colorectal-tumor development,” The New England Journal of Medicine, 319,525-32, 1 September 1988. Bert Vogelstein (Molecular Genetics Laboratory, Johns Hopkins Oncology Center, Baltimore): “It is widely believed that cancer is the result of a series of genetic alterations. This paper is important because it lends substantial support to this belief with regard to one of the most common hu