Measles virus induces regression of lymphoma

Measles virus can induce regression of human B-cell lymphoma xenografts in severe combined immunodeficient mice.

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

An alternative to standard gene-therapy approaches to cancer treatment is the use of various viruses with lytic effects on human cancer cells. In June 15 Blood, Deanna Grote and colleagues from the Mayo Clinic Rochester, Minnesota, show that live attenuated measles virus can induce regression of human B-cell lymphoma xenografts in severe combined immunodeficient mice.

Grote et al investigated the cytoreductive potential of MV-Ed (a derivative of the Edmonston-B strain of measles virus) in murine models of aggressive and indolent B-cell lymphoma. Both intratumoural and intravenous injection of MV-Ed induced regression of large established human lymphoma xenografts after 15 to 25 days, in contrast to control therapy with UV-inactivated virus, in which all tumours progressed. Analysis of residual tumour confirmed replication of MV within the malignant cells (Blood 2001, 97:3746-3754).

In addition, they showed that MV increased tumour expression of heat shock protein and speculate that this may enhance the ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Meet the Author

  • Tudor Toma

    This person does not yet have a bio.
Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
Explore polypharmacology’s beneficial role in target-based drug discovery

Embracing Polypharmacology for Multipurpose Drug Targeting

Fortis Life Sciences
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 

Products

Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit

BIOVECTRA

BIOVECTRA is Honored with 2025 CDMO Leadership Award for Biologics

Sino Logo

Gilead’s Capsid Revolution Meets Our Capsid Solutions: Sino Biological – Engineering the Tools to Outsmart HIV

Stirling Ultracold

Meet the Upright ULT Built for Faster Recovery - Stirling VAULT100™

Stirling Ultracold logo