The identification of alleles associated with complex hearing defects, such as presbyacusis (age-related hearing loss, AHL), presents a formidable challenge to geneticists. In the February
Mitochondrial mutation associated with hearing loss
The identification of alleles associated with complex hearing defects, such as presbyacusis (age-related hearing loss, AHL), presents a formidable challenge to geneticists. In the February Nature Genetics Johnson et al. describe their use of elegant mouse breeding experiments to identify the first example of a mitochondrial DNA (mtDNA) mutation that acts as a modifier of a nuclear AHL locus (Nat Genet 2001, 27:191-194). They performed a series of reciprocal backcrosses between three hearing-impa

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