A. Noda, Y. Ning, S.F. Venable, O.M. Pereira-Smith, J.R. Smith, "Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen," Experimental Cell Research, 211:90-8, 1994. (Cited in nearly 150 publications through August 1995)

Comments by James R. Smith, Baylor College of Medicine The major finding described in this paper, says James R. Smith, a professor in the division of molecular virology at Baylor College of Medicine and codirector of the Roy M. and Phyllis Gough Huffington Center on Aging there, is "the cloning and identification of genes that inhibit cell proliferation."

Richard Wilkerson AFTER ANOPHELES: DOD's Richard Wilkerson seeks out malaria-carrying mosquitoes in Brazil.

Smith's research group, whose focus is the study of cellular aging, first targeted the genes because "they were overexpressed in senescent human cells." Senescence is a stage in the cellular growth cycle marked by a blockage in DNA synthesis and cessation of cell division....

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