Mouse Study Suggests Fibromyalgia Has Autoimmune Roots

When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.

Written byAnnie Melchor
| 2 min read
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Because the most common symptoms of fibromyalgia involve pain and problems with motor control, the prevailing view is that dysfunction in the nervous system causes the disease. But a study published Thursday (July 1) in The Journal of Clinical Investigation suggests the disease may actually be caused by antibodies that interact with the nervous system.

“The widespread paradigm at the moment is that this is a disease that emanates from the brain,” lead author David Andersson of King’s College London tells The Guardian. “I think our findings suggest that that’s not the case.”

Fibromyalgia syndrome (FMS) is a painful and poorly understood chronic illness that causes widespread pain, emotional distress, fatigue, and brain fog. The Centers for Disease Control and Prevention estimates that it affects at least 2 percent of the adult population in the US, and according to The Guardian, 80 percent ...

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    Stephanie "Annie" Melchor got her PhD from the University of Virginia in 2020, studying how the immune response to the parasite Toxoplasma gondii leads to muscle wasting and tissue scarring in mice. While she is still an ardent immunology fangirl, she left the bench to become a science writer and received her master’s degree in science communication from the University of California, Santa Cruz, in 2021. You can check out more of her work here.

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