Mouse Study Suggests Fibromyalgia Has Autoimmune Roots

When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.

Written byAnnie Melchor
| 2 min read
a pink and purple micrograph of a longitudinal section of human spinal ganglion cells

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

ABOVE: Human spinal ganglion cells
© ISTOCK.COM, WEISSCHR

Because the most common symptoms of fibromyalgia involve pain and problems with motor control, the prevailing view is that dysfunction in the nervous system causes the disease. But a study published Thursday (July 1) in The Journal of Clinical Investigation suggests the disease may actually be caused by antibodies that interact with the nervous system.

“The widespread paradigm at the moment is that this is a disease that emanates from the brain,” lead author David Andersson of King’s College London tells The Guardian. “I think our findings suggest that that’s not the case.”

Fibromyalgia syndrome (FMS) is a painful and poorly understood chronic illness that causes widespread pain, emotional distress, fatigue, and brain fog. The Centers for Disease Control and Prevention estimates that it affects at least 2 percent of the adult population in the US, and according to The Guardian, 80 percent ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • black and white photograph of stephanie melchor

    Stephanie "Annie" Melchor got her PhD from the University of Virginia in 2020, studying how the immune response to the parasite Toxoplasma gondii leads to muscle wasting and tissue scarring in mice. While she is still an ardent immunology fangirl, she left the bench to become a science writer and received her master’s degree in science communication from the University of California, Santa Cruz, in 2021. You can check out more of her work here.

    View Full Profile
Share
Image of small blue creatures called Nergals. Some have hearts above their heads, which signify friendship. There is one Nergal who is sneezing and losing health, which is denoted by minus one signs floating around it.
June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

View this Issue
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo
Unraveling Complex Biology with Advanced Multiomics Technology

Unraveling Complex Biology with Five-Dimensional Multiomics

Element Bioscience Logo
Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Twist Bio 
The Scientist Placeholder Image

Seeing and Sorting with Confidence

BD

Products

The Scientist Placeholder Image

Waters Enhances Alliance iS HPLC System Software, Setting a New Standard for End-to-End Traceability and Data Integrity 

The Scientist Placeholder Image

Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

agilent-logo

Agilent Announces the Enhanced 8850 Gas Chromatograph

parse-biosciences-logo

Pioneering Cancer Plasticity Atlas will help Predict Response to Cancer Therapies