This year’s awards recognize work on integrins, noninvasive prenatal screening, and COVID-19 data-tracking.

A bacterium that produces an insulin-like peptide can give mice type 1 diabetes, and infection with the microbe seems to predict the onset of the disease in humans, a study finds.

Genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions, a study finds.

Several lines of evidence suggest that targeting the body’s defense pathways might help treat a subset of people with the psychiatric disorder. But many open questions remain.

Scientists have pinpointed several pathways through which the immune system could disrupt neuronal functioning and thereby lead to psychotic symptoms.

Making specific alterations to the bacterial population in a rat’s lungs either better protects the animals against multiple sclerosis–like symptoms or makes them more vulnerable, a study finds—the first demonstration of a lung-brain axis.

Roseolovirus infection disrupts how the body trains immune cells not to attack it, a mouse study shows.

Experts say new research provides strong evidence that a common herpesvirus can trigger the chronic inflammatory disease.

Immunologists and parasitologists are working to revive the idea that helminths, and more specifically the molecules they secrete, could help treat allergies and autoimmune disease.

Research in animals and people supports a range of mechanisms by which the parasites affect physiology and immune responses.

Researchers report what appears to be the second case of a person’s immune system clearing the virus on its own.

The Scientist spoke with Rachel Zeig-Owens, the director of epidemiology for the World Trade Center Health Program, about what scientists have learned after two decades of studying illness and disease among survivors.

When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.

Stronger interferon production, greater T cell activation, and increased susceptibility to autoimmunity are just some of the ways that females seem to differ from males.

The Johns Hopkins University researcher bucked the prevailing idea that the body would not launch an immune response against its own tissues, and in doing so established an entirely new scientific discipline.

A handful of viruses have been associated with long-term, debilitating symptoms in a subset of those who become infected. Early signs hint that SARS-CoV-2 may do the same.

The presence of a particular set of RNAs in the blood forewarns of an onset of severe symptoms and points to the cells involved.

Many dominant T cell variants decline during pregnancy and reappear afterward, possibly explaining why relapses of the autoimmune disease are less common when women are expecting.