Morphine Tolerance Pathway Identified in Mice
Morphine Tolerance Pathway Identified in Mice
Prolonged exposure to morphine triggers cells in the spine to release signaling molecules that increase pain sensitivity and dull the relief of the drug. Blocking this activity could improve pain management.
Morphine Tolerance Pathway Identified in Mice
Morphine Tolerance Pathway Identified in Mice

Prolonged exposure to morphine triggers cells in the spine to release signaling molecules that increase pain sensitivity and dull the relief of the drug. Blocking this activity could improve pain management.

Prolonged exposure to morphine triggers cells in the spine to release signaling molecules that increase pain sensitivity and dull the relief of the drug. Blocking this activity could improve pain management.

chronic pain
Low Frequency Electric Stimulation Can Treat Back Pain: Study
Low Frequency Electric Stimulation Can Treat Back Pain: Study
Emma Yasinski | Sep 2, 2021
Patients in a small trial said their chronic pain improved an average of 90 percent over the course of 15 days, but returned shortly after the electrical stimulation sessions ended.
Mouse Study Suggests Fibromyalgia Has Autoimmune Roots
Mouse Study Suggests Fibromyalgia Has Autoimmune Roots
Annie Melchor | Jul 2, 2021
When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.
Pain Researcher Quits Academia, Takes Lab Home with Him
Pain Researcher Quits Academia, Takes Lab Home with Him
Jef Akst | May 1, 2021
After resigning from the University of New England last year, Geoffrey Bove continues to study the effects of massage on rats in a facility he set up in his house.
Macrophages in Mice Shuttle Mitochondria to Neurons in Need
Macrophages in Mice Shuttle Mitochondria to Neurons in Need
Katarina Zimmer | Mar 5, 2020
The findings could represent a novel mechanism for relieving inflammatory pain.
Image of the Day: Viral Residue
Image of the Day: Viral Residue
Nicoletta Lanese | Aug 30, 2019
Genetic material from the chikungunya virus remains in mouse cells after infection and may be linked to later joint pain.
Special Schwann Cells in Mice Play Unsung Role in Pain
Special Schwann Cells in Mice Play Unsung Role in Pain
Nicoletta Lanese | Aug 16, 2019
The glia seem to make up part of a newly described sensory organ, the discoverers suggest.
Men React to Repeated Painful Experiences Differently than Women Do
Men React to Repeated Painful Experiences Differently than Women Do
Diana Kwon | Jan 14, 2019
Men’s pain tolerance decreases when exposed to a setting where they’ve previously had a painful experience.
Synthetic Botox Treats Chronic Pain in Mice
Synthetic Botox Treats Chronic Pain in Mice
Abby Olena | Jul 18, 2018
Researchers silence pain neurons in the mouse spinal cord with injections of botulinum toxins modified to bind to the neurons’ receptors.
Glial Ties to Persistent Pain
Glial Ties to Persistent Pain
Mark R. Hutchinson | Jan 1, 2018
Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.
Contributors
Contributors
Jef Akst and Katarina Zimmer | Jan 1, 2018
Meet some of the people featured in the January 2018 issue of The Scientist.
Prizes and Penalties
Prizes and Penalties
Bob Grant | Jan 1, 2018
Life is filled with pleasure and pain. Science and society are struggling mightily with both.
Targeting Sodium Channels for Pain Relief
Targeting Sodium Channels for Pain Relief
Catherine Offord | Jan 1, 2018
The race to develop analgesic drugs that inhibit sodium channel NaV1.7 is revealing a complex sensory role for the protein.
Painful Realities
Painful Realities
The Scientist Staff | Dec 31, 2017
Dave Thomas, a researcher at the National Institute on Drug Abuse, talks about the harsh truths and frustrating complexity of pain and analgesia.
Infographic: A Painful Pathway
Infographic: A Painful Pathway
Catherine Offord | Dec 31, 2017
Since the mid-2000s, the voltage-gated sodium channel NaV1.7 has emerged as a promising target for a new class of analgesics.
Infographic: Two Pain Paths Diverge in the Body
Infographic: Two Pain Paths Diverge in the Body
Mark R. Hutchinson | Dec 31, 2017
The acute pain that results from injury or disease is very different from chronic pain.
Optogenetic Therapies Move Closer to Clinical Use
Optogenetic Therapies Move Closer to Clinical Use
Shawna Williams | Nov 16, 2017
With a clinical trial underway to restore vision optogenetically, researchers also see promise in using the technique to treat deafness, pain, and other conditions.
Oxford University to Study Marijuana
Oxford University to Study Marijuana
Kerry Grens | Mar 20, 2017
Academics partner with a biotech firm to investigate cannabinoids and develop potential therapeutics.
Toward a Nonaddictive Opioid
Toward a Nonaddictive Opioid
Ben Andrew Henry | Aug 18, 2016
A newly discovered painkiller does not cause respiratory depression or addiction in mice and could be an alternative to frequently abused prescription medicines, researchers report.