Patients in a small trial said their chronic pain improved an average of 90 percent over the course of 15 days, but returned shortly after the electrical stimulation sessions ended.

When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.

After resigning from the University of New England last year, Geoffrey Bove continues to study the effects of massage on rats in a facility he set up in his house.

The findings could represent a novel mechanism for relieving inflammatory pain.

Genetic material from the chikungunya virus remains in mouse cells after infection and may be linked to later joint pain.

The glia seem to make up part of a newly described sensory organ, the discoverers suggest.

Men’s pain tolerance decreases when exposed to a setting where they’ve previously had a painful experience.

Researchers silence pain neurons in the mouse spinal cord with injections of botulinum toxins modified to bind to the neurons’ receptors.

Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.

Meet some of the people featured in the January 2018 issue of The Scientist.

Life is filled with pleasure and pain. Science and society are struggling mightily with both.

The race to develop analgesic drugs that inhibit sodium channel Na_V1.7 is revealing a complex sensory role for the protein.

Dave Thomas, a researcher at the National Institute on Drug Abuse, talks about the harsh truths and frustrating complexity of pain and analgesia.

Since the mid-2000s, the voltage-gated sodium channel Na_V1.7 has emerged as a promising target for a new class of analgesics.

The acute pain that results from injury or disease is very different from chronic pain.

With a clinical trial underway to restore vision optogenetically, researchers also see promise in using the technique to treat deafness, pain, and other conditions.

Academics partner with a biotech firm to investigate cannabinoids and develop potential therapeutics.

A newly discovered painkiller does not cause respiratory depression or addiction in mice and could be an alternative to frequently abused prescription medicines, researchers report.