Genetic variants that reduce the editing levels of double-stranded RNA are associated with autoimmune and immune-mediated conditions, a study finds.

Several lines of evidence suggest that targeting the body’s defense pathways might help treat a subset of people with the psychiatric disorder. But many open questions remain.

Scientists have pinpointed several pathways through which the immune system could disrupt neuronal functioning and thereby lead to psychotic symptoms.

Roseolovirus infection disrupts how the body trains immune cells not to attack it, a mouse study shows.

Immunologists and parasitologists are working to revive the idea that helminths, and more specifically the molecules they secrete, could help treat allergies and autoimmune disease.

Research in animals and people supports a range of mechanisms by which the parasites affect physiology and immune responses.

When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.

Stronger interferon production, greater T cell activation, and increased susceptibility to autoimmunity are just some of the ways that females seem to differ from males.

The presence of a particular set of RNAs in the blood forewarns of an onset of severe symptoms and points to the cells involved.

By revealing that animals could develop immune responses against their own tissues, the physician-scientist established an entirely new field of science.

Molecules produced by resident bacteria and their hosts may signal immune cells to attack the body’s own tissues.

Antigens originating from the microbiome may trigger an autoimmune response.

The second phase of the Human Microbiome Project reports on microbial composition in prediabetes, inflammatory bowel disease, and pregnancy.