Conceptual image of a person's brain with a cluster of cells inside
Is the Immune System to Blame for Schizophrenia?
Several lines of evidence suggest that targeting the body’s defense pathways might help treat a subset of people with the psychiatric disorder. But many open questions remain.
ABOVE: Modified from © istock.com, Viki, yodiyim
Is the Immune System to Blame for Schizophrenia?
Is the Immune System to Blame for Schizophrenia?

Several lines of evidence suggest that targeting the body’s defense pathways might help treat a subset of people with the psychiatric disorder. But many open questions remain.

Several lines of evidence suggest that targeting the body’s defense pathways might help treat a subset of people with the psychiatric disorder. But many open questions remain.

ABOVE: Modified from © istock.com, Viki, yodiyim

autoimmunity

Illustration comparing neural pathway and the humoral pathway
Infographic: How the Body’s Defenses Attack the Brain
Diana Kwon | Apr 18, 2022
Scientists have pinpointed several pathways through which the immune system could disrupt neuronal functioning and thereby lead to psychotic symptoms.
illustration of thymus in white on a green background
New Mechanism for Virus-Triggered Autoimmunity Uncovered
Sophie Fessl | Mar 11, 2022
Roseolovirus infection disrupts how the body trains immune cells not to attack it, a mouse study shows.
Erika More developed a jello-like tissue system to study how immune cells stimulate tissues and blood vessel growth.
An Engineer’s Perspective on Autoimmunity
Aparna Nathan | Dec 10, 2021
Erika Moore builds biomaterials to study disparate lupus outcomes.
3D illustration of a tapeworm infestation in a human intestine
Return of the Worms
Catherine Offord | Dec 1, 2021
Immunologists and parasitologists are working to revive the idea that helminths, and more specifically the molecules they secrete, could help treat allergies and autoimmune disease.
December 2021 - Gut Guests - Infographic
Infographic: How Worms that Reside in the Gut Could Influence Health
Catherine Offord | Dec 1, 2021
Research in animals and people supports a range of mechanisms by which the parasites affect physiology and immune responses.
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Helping the Immune System Keep its Cool
Aparna Nathan | Dec 10, 2021
Researchers found that lowering the temperature alleviates autoimmunity in mice.
a pink and purple micrograph of a longitudinal section of human spinal ganglion cells
Mouse Study Suggests Fibromyalgia Has Autoimmune Roots
Annie Melchor | Jul 2, 2021
When researchers injected mice with antibodies from fibromyalgia patients, the animals developed symptoms of the disease—suggesting that it may be controlled by the immune system, not the nervous system.
Sex Differences in Immune Responses to Viral Infection
Catherine Offord | Mar 1, 2021
Stronger interferon production, greater T cell activation, and increased susceptibility to autoimmunity are just some of the ways that females seem to differ from males.
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A Double-Edged Sword: When the Immune System Turns Against Us
The Scientist Creative Services Team | Oct 29, 2021
Klaus Ley and Neeloffer Mookherjee will explore the relationships between inflammation, autoimmunity, and pathology.
Identified: Molecular Predictors of Rheumatoid Arthritis Relapse
Ruth Williams | Jul 15, 2020
The presence of a particular set of RNAs in the blood forewarns of an onset of severe symptoms and points to the cells involved.
The Father of Autoimmunity: A Profile of Noel Rose
Diana Kwon | Jun 1, 2020
By revealing that animals could develop immune responses against their own tissues, the physician-scientist established an entirely new field of science.
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How Cellular Heterogeneity Drives Immune Responses
The Scientist Creative Services Team in collaboration with 10x Genomics | Sep 28, 2021
An expert panel will discuss how single cell multiomic techniques shed new light on immune cell heterogeneity and immune function.
microbiome
Do Commensal Microbes Stoke the Fire of Autoimmunity?
Amanda B. Keener | Jun 1, 2019
Molecules produced by resident bacteria and their hosts may signal immune cells to attack the body’s own tissues.
Commensal Mimicry in Autoimmune Disease
Infographic: Commensal Mimicry in Autoimmune Disease
Amanda B. Keener | Jun 1, 2019
Antigens originating from the microbiome may trigger an autoimmune response.
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Engineered Yeast Robots Destroy Inflammatory Molecules in an IBD Mouse Model
Roni Dengler, PhD | Aug 16, 2021
Scientists added a gene circuit that senses and neutralizes proinflammatory ATP to yeast, taking another step towards precision medicine.
bacterial vaginosis vagina microbiome pregnancy prematurity
Three Studies Track People’s Microbiomes Through Health and Disease
Emma Yasinski | May 29, 2019
The second phase of the Human Microbiome Project reports on microbial composition in prediabetes, inflammatory bowel disease, and pregnancy.
CAR T Cells Treat Lupus in Mice
Abby Olena | Mar 6, 2019
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease.
Immune Response to Gut Microbes Linked to Diabetes Risk
Abby Olena | Feb 1, 2019
Researchers find that it’s not just high-risk genes, but how children’s bodies respond to their own intestinal microbiota that relates to future diagnoses of type 1 diabetes.
Image of the Day: Telling Scans
Aggie Mika | Oct 16, 2017
In children’s brain scans, scientists uncovered signs of multiple sclerosis before the kids showed any symptoms of the disease.