Turning off a well-known chemical switch may allow severed nerves in adult mammals to regenerate, according to a report in this week's
Previous research that sought to explain why mammalian axons fail to regenerate in the wounded brain or spinal cord found several inhibitory cues that prevent healing. The culprits include proteins associated with myelin and proteoglycans released by the glial scar that forms after neural injury.
In a search for a signal that might override this chemical blockade, a group led by Zhigang He of Children's Hospital in Boston, Mass. cultured neurons on a myelin substrate. They screened approximately 400 candidate compounds, looking for those that...