Mouse Brains Appear to Eavesdrop on Their Fat

For the first time, a team visualizes sensory nerves projecting into adipose tissue in mice and finds these neuronal cells may counteract the local effects of the sympathetic nervous system.

Written byAlejandra Manjarrez, PhD
| 4 min read
Adipose tissue under the microscope appearing as red blobs on a white background
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Brain and fat are well acquainted with each other. We know, for example, that fat cells secrete hormones that signal the brain when to stop eating. This exchange of messages can be rather slow, though, as it takes time for hormones to travel from fat into the bloodstream to the brain.

A study published August 31 in Nature, however, suggests that fat may be sending much faster messages to the brain. The work provides evidence that somatosensory cells—the ones that warn us if something is cold or painful—innervate the adipose tissue of mice, hinting that these neurons may sense something in the fat, potentially prompting a reaction as fast as jerking a hand away from a hot stovetop. But what that something might be, and its effects on the brain, remain unknown for now.

This is a “really nice paper,” says University of Oxford neuroscientist Ana Domingos, who was not ...

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Meet the Author

  • alejandra manjarrez

    Alejandra Manjarrez is a freelance science journalist who contributes to The Scientist. She has a PhD in systems biology from ETH Zurich and a master’s in molecular biology from Utrecht University. After years studying bacteria in a lab, she now spends most of her days reading, writing, and hunting science stories, either while traveling or visiting random libraries around the world. Her work has also appeared in Hakai, The Atlantic, and Lab Times.

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