Opening a Can of Worms

A father’s determination to help his son resulted in an experimental treatment for autism that uses roundworms to modulate inflammatory immune responses. Can the worms be used to treat other diseases?

Written byBob Grant
| 13 min read

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Nematode parasite, Trichuris suis, found in the intestines of pigsOVAMED In 2005 the Johnson family was at its breaking point. Lawrence, the family’s 13-year-old son, was diagnosed with autism at age two and a half, and his parents had valiantly coped with his illness for the ensuing decade.

Throughout his childhood, Lawrence’s disorder progressed along the typical path: he would not engage in pretend play like other children, he repeated himself incessantly, his interests were very restricted, and he was frequently agitated and anxious.

By his teenage years, Lawrence had veered into the dangerous realm of self abuse. He smashed his head against the wall dozens of times a day. He bit himself until he bled. He gouged at his eyes and tore at his face. A normal school experience was virtually impossible. He couldn’t walk a single block from the family’s Brooklyn brownstone without kicking and screaming when a traffic light changed at the wrong moment or streets were crossed in an unacceptable order. “If people haven’t actually experienced those symptoms of ...

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Meet the Author

  • From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer. Before joining the team, he worked as a reporter at Audubon and earned a master’s degree in science journalism from New York University. In his previous life, he pursued a career in science, getting a bachelor’s degree in wildlife biology from Montana State University and a master’s degree in marine biology from the College of Charleston in South Carolina. Bob edited Reading Frames and other sections of the magazine.

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