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ONI

ONI is a private, venture backed life sciences tools company transforming therapeutic discovery with accessible, high-performance super-resolution microscopy and funded by ARCH Venture Partners, Casdin Captial, Oxford Science Enterprises (OSE) and more. The company’s first product, the Nanoimager, introduced the world’s first desktop platform for single-molecule imaging, offering 20 nm resolution to study individual molecules in living cells, tissue, and nanoparticles. ONI’s latest innovation, the Aplo Scope, is a compact, end-to-end imaging platform that delivers unmatched clarity, precision, and speed. Designed to empower researchers, the Aplo Scope provides real-time insights into complex biological systems, enabling breakthroughs in drug delivery, biomarker discovery, and antibody therapeutics.

Content by ONI

3D rendering of RNA strands and a lipid nanoparticle

Super-Resolution Imaging Transforms LNP Characterization

A blurry image of a Christmas tree and fireplace.

Pushing Imaging Limits with Super-Resolution Microscopy

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ONI’s LNP Profiler Kit with AutoLNP sets new standard for Lipid Nanoparticle characterization with Super-Resolution Microscopy

Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

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Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

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Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

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Products

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Research on rewiring neural circuit in fruit flies wins 2025 Eppendorf & Science Prize

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EVIDENT's New FLUOVIEW FV5000 Redefines the Boundaries of Confocal and Multiphoton Imaging

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EVIDENT Launches Sixth Annual Image of the Year Contest

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10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research