Enhancing T cell responses with specific mAbs can mediate the regression of selected murine tumors, but several cancers remain resistant to such treatments. In March 1
Wilcox et al. showed that it is immunological ignorance (rather than anergy or deletion of specific cytotoxic T lymphocytes -CTLs) that prevented an anti CD137 mAb from activating tumor immunity in established C3 lymphomas, TC-1 lung carcinoma and B16-F10 melanoma models. But immunization with the CD137 did break the immune ignorance. CD137 immunization was insufficient to stimulate a curative CTL response, but when associated with anti–CD137 mAb induced a CTL response leading to the regression of established tumors (J Clin Invest 2002, ...