Metastasis poses the greatest threat to the survival of cancer patients, yet the molecular events underlying this complex process are unclear. In the October 11
They developed an immunoaffinity fractionation procedure to purify colorectal epithelial cells away from contaminating hepatic cells. They then analysed 95,000 tags, representing over 17,000 transcripts, and identified 144 transcripts upregulated in metastatic cells. Experimental verification showed that one gene,