Potential for muscle regeneration

A novel population of muscle stem cells from mice could hold the key to the treatment of muscle-wasting diseases.

| 1 min read

Register for free to listen to this article
Listen with Speechify
0:00
1:00
Share

Replacement of skeletal muscle could be a powerful tool the treatment of muscle-wasting conditions such as Duchenne dystrophy, but only a limited number of cell types are known to have myoregenerative properties. In 13 May Journal of Cell Biology, Zhuqing Qu-Petersen and colleagues from University of Pittsburgh, USA, describe a novel population of murine muscle stem cells, which can proliferate, make dystrophin and improve muscle regeneration (DOI: 10.1083/jcb.200108150).

Qu-Petersen et al. used a modified version of the preplate technique and isolated three novel myogenic cell populations from the muscle of healthy newborn mice. One population — the third to be examined — was composed of long-time proliferating cells that express hematopoietic stem cell markers. These cells can differentiate into muscle, neural and endothelial lineages both in vitro and in vivo. In addition, the transplantation of the long-time proliferating cells improved the efficiency of muscle regeneration and dystrophin delivery to dystrophic ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Meet the Author

  • Tudor Toma

    This person does not yet have a bio.
Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo
New Frontiers in Vaccine Development

New Frontiers in Vaccine Development

Sino

Products

Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide

Explore a Concise Guide to Optimizing Viral Transduction

A Visual Guide to Lentiviral Gene Delivery

Takara Bio
Inventia Life Science

Inventia Life Science Launches RASTRUM™ Allegro to Revolutionize High-Throughput 3D Cell Culture for Drug Discovery and Disease Research

An illustration of differently shaped viruses.

Detecting Novel Viruses Using a Comprehensive Enrichment Panel

Twist Bio