Profile: Dean Buonomano Studies How the Brain Encodes Time

The UCLA neurobiologist uses computational modeling, in vitro electrophysiology, and human psychophysics experiments to explore how neurons and the brain as a whole perceive and respond to time.

Written byAnna Azvolinsky
| 9 min read

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DEAN BUONOMANO
Professor of Behavioral Neuroscience, Neurobiology Brain Research Institute
University of California, Los Angeles
COURTESY OF DEAN BUONOMANO
Dean Buonomano was among the first neuroscientists to begin to ask how the human brain encodes time. It’s not an easy concept to grasp, Buonomano says, and for that reason many researchers overlook it. “The first field of modern science was probably geometry, which was formalized by Euclid around 300 B.C.,” says the researcher, who is currently working on a popular-science book about time and the brain. “What’s amazing about geometry is that there is absolutely no time involved; it’s the study of things that never change. And there’s a reason why it is one of the first science fields. Science is much easier if you can ignore time.”

Buonomano was in grad school when he became enamored of the question of how we navigate through time. As a graduate student at the University of Texas (UT) Health Science Center at Houston, Buonomano collaborated with Michael Mauk after he heard Mauk’s lecture on his studies of the neural circuits in the cerebellum. “He had really transformative ideas about how the cerebellum tells time and how the dynamics of neural circuits in the cerebellum might code for timing,” says Buonomano. “His ideas were really something that directed the rest of my career.”

Mauk and Buonomano modeled the way the cerebellum’s circuits could respond to stimuli and showed that this type of neuronal network can differentiate between time intervals that differ by just tens of milliseconds. ...

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    Anna Azvolinsky received a PhD in molecular biology in November 2008 from Princeton University. Her graduate research focused on a genome-wide analyses of genomic integrity and DNA replication. She did a one-year post-doctoral fellowship at Memorial Sloan Kettering Cancer Center in New York City and then left academia to pursue science writing. She has been a freelance science writer since 2012, based in New York City.

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