The ends of vertebrate chromosomes are protected by telomeric structures containing several kilobases of short repeated sequences (TTAGGG). In the January
Putting an end to chromosome stability
The ends of vertebrate chromosomes are protected by telomeric structures containing several kilobases of short repeated sequences (TTAGGG). In the January Molecular and Cellular Biology Kilburn et al. describe their investigation of the effect of telomeric repeats inserted at defined intrachromosomal locations (Mol Cell Biol 2001, 21:126-135). They used site-specific recombination to place an 800 nucleotide fragment from a functional vertebrate telomere repeat, in either orientation, within a sp

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Jonathan Weitzman
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