A screen of diploid yeast mutants has identified over a hundred genes involved in the response to ionizing radiation.
Cells must be able to recognize and repair DNA damage if they are to tolerate the effects of radiation. Much of our understanding of mammalian repair mechanisms, and their involvement in cancer, has come from studying yeast. In the Advanced Online Publication issue of
They screened a set of diploid
Many of these are also involved in resistance to other DNA-damaging agents, such as ultraviolet irradiation or genotoxic drugs. Several ...
In mammals, intracellular clocks begin to tick within days of fertilization.
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