Ras controls herpes virus penetration in cells

The molecular basis of host-cell permissiveness to herpes simplex viruses (HSV) is under intense investigation because of HSV prevalence in human disease and its potential use as an anti-cancer therapeutic. In August Nature Cell Biology, Faris Farassati and colleagues from the University of Calgary, Alberta, Canada show for the first time that oncogenes in Ras signalling pathway are essential in host-cell permissiveness to herpes simplex virus 1.

Farassati et al. exposed to the HSV-1 virus (strain F) parental Swiss mouse embryo fibroblasts (NIH-3T3 cells) and NIH-3T3 cells transformed with the oncogenes v-erbB, sos or ras — all activators of the Ras signalling pathway. Permissiveness to HSV-1 infection (assessed by induction of cytopathic effects, viral protein synthesis and virus output) was significantly increased in NIH-3T3 cells transformed with Ras activators. In addition inhibitors of the Ras signalling pathway, such as farnesyl transferase inhibitor 1 and PD98059, effectively suppressed HSV-1 infection of ...