Malaria sporozoitesFLICKR, NIAIDThe malaria vaccine doesn’t provide lasting protection against the mosquito-borne disease, according to a study published yesterday (June 29) in NEJM: it delays infections by several years instead. This seven-year follow-up on a Phase II clinical trial of the RTS,S vaccine in African children found the immunization to be only marginally effective, causing a “rebound effect” in which vaccinated children became infected with malaria several years later, the authors reported.
“Is delaying the age at which most of the malaria occurs going to be good or bad or indifferent?” study coauthor Philip Bejon of the KEMRI-Wellcome Trust Research Program in Kilifi, Kenya, told STAT News. “We don’t really know.”
Bejon and colleagues conducted a double-blind, randomized controlled trial of the vaccine, made by GlaxoSmithKline, in 447 children who were between 5 months and 17 months of age at the time of the first vaccination. In the initial trial, the children were given three doses of the vaccine or a control (rabies) vaccine over a period of two months. Some children were later given a fourth dose.
Four years after immunization, the malaria vaccine provided almost no protection against contracting the disease. In fact, five years ...
