Systems Immunology: Understanding Responses to Vaccination and Infection

Systems Immunology: Understanding Responses to Vaccination and Infection from thescientistllc on Vimeo.

Systems immunology is a new and rapidly developing field of research providing quantitative molecular profiles of patients' immune responses, made possible by recent advances in multiple technological platforms. The human-centered approach has invigorated vaccine research and shown promise to enhance our knowledge of the systemic immune response to vaccination and infection that was not possible with classical, animal-model based approaches. Techniques that make use of peripheral blood to survey systemic immune responses include next-generation sequencing coupled to bioinformatic analysis, gene and protein microarrays, metabolomics, multiparameter flow cytometry, mass cytometry, and multiplex cytokine and chemokine assays. The Scientist is bringing together a panel of experts to present their research in systems immunology and provide insight into this exciting new field.

Topics to be covered:

• New insights into immune responses to infection through data-driven analysis of multiplexed single-cell data...