Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.
Alzheimer’s-Linked Mutation Causes Blockages in Neurons
Alzheimer’s-Linked Mutation Causes Blockages in Neurons

The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.

The variant causes a buildup of BACE1 protein in axons in cultured neurons and mice. Researchers say it might be time to rethink failed trials that inhibit BACE1 to treat the neurodegenerative disease.

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First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease
Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease
Ian Le Guillou | Sep 28, 2020
These “coarse-grained” plaques resemble those that clog up the brain’s blood vessels in a different disease, pointing to links between the vascular system and the neurodegenerative disease.
Poor Sleep Linked with Future Amyloid-β Build Up
Poor Sleep Linked with Future Amyloid-β Build Up
Abby Olena | Sep 11, 2020
Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.
Experimental Blood Test Could Flag Alzheimer’s
Experimental Blood Test Could Flag Alzheimer’s
Kerry Grens | Jul 29, 2020
New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.
Iconoclastic Alzheimer’s Researcher Robert Moir Dies
Iconoclastic Alzheimer’s Researcher Robert Moir Dies
Shawna Williams | Jan 2, 2020
The 58-year-old was best known for uncovering evidence of a link between pathogens and the neurodegenerative disease.
<em>APOE</em> Mutation Linked to Protection From Alzheimer&rsquo;s: Case Study
APOE Mutation Linked to Protection From Alzheimer’s: Case Study
Catherine Offord | Nov 5, 2019
A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.
Chemist Christopher Dobson Dies
Chemist Christopher Dobson Dies
Ashley Yeager | Sep 16, 2019
The University of Cambridge scholar’s research on folding proteins advanced scientists’ understanding of illnesses, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes.
Image of the Day: Alzheimer&rsquo;s GenesImage of the Day: Alzheimer&rsquo;s Genes
Image of the Day: Alzheimer’s Genes
Nicoletta Lanese | Aug 19, 2019
Mutations within the MS4A gene cluster have been linked to changes in protein levels that affect disease risk.
Rapidly Flashing Lights and Sounds Reduces Alzheimer&rsquo;s in Mice
Rapidly Flashing Lights and Sounds Reduces Alzheimer’s in Mice
Jef Akst | Mar 15, 2019
Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.