Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

amyloid beta plaques
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss
Chloe Tenn | Oct 8, 2021
A new study links a variant of the apolipoprotein E gene called APOE ε4 to better memory in older age, even in the presence of amyloid plaques—a possible explanation for the variant’s persistence despite its association with an increased risk of Alzheimer’s disease.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Sruthi S. Balakrishnan | Oct 1, 2021
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
Updated
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews
Kerry Grens | Jun 7, 2021
A lackluster performance in clinical trials of the monoclonal antibody aducanumab has left some experts unconvinced of its benefit.
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
First Alzheimer’s Blood Test Rolled Out for Clinical Use in US
Shawna Williams | Nov 2, 2020
The test will be a cheaper and more accessible alternative to currently available diagnostic tools, researchers say.
Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease
Newly Found Alzheimer’s Plaque Type Linked to Early-Onset Disease
Ian Le Guillou | Sep 28, 2020
These “coarse-grained” plaques resemble those that clog up the brain’s blood vessels in a different disease, pointing to links between the vascular system and the neurodegenerative disease.
Poor Sleep Linked with Future Amyloid-β Build Up
Poor Sleep Linked with Future Amyloid-β Build Up
Abby Olena | Sep 11, 2020
Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.
Experimental Blood Test Could Flag Alzheimer’s
Experimental Blood Test Could Flag Alzheimer’s
Kerry Grens | Jul 29, 2020
New studies show that elevated levels of a form of tau called p-tau217 can accurately distinguish Alzheimer’s disease from other forms of dementia, and perhaps even predict it.
Biogen, Eisai End Two Late-Stage Trials for Alzheimer’s Treatment
Biogen, Eisai End Two Late-Stage Trials for Alzheimer’s Treatment
Emily Makowski | Sep 16, 2019
The widely expected move comes months after the companies scrapped trials of another Alzheimer’s drug.
Rapidly Flashing Lights and Sounds Reduces Alzheimer’s in Mice
Rapidly Flashing Lights and Sounds Reduces Alzheimer’s in Mice
Jef Akst | Mar 15, 2019
Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.
Herpes Viruses Implicated in Alzheimer’s Disease
Herpes Viruses Implicated in Alzheimer’s Disease
Anna Azvolinsky | Jun 21, 2018

A new study shows that the brains of Alzheimer’s disease patients have a greater viral load, while another study in mice shows infection leads to amyloid-β build up.

Researchers Develop Potential Blood Test for Alzheimer’s Disease
Researchers Develop Potential Blood Test for Alzheimer’s Disease
Catherine Offord | Feb 1, 2018
The test uses levels of plasma amyloid-β to estimate the buildup of protein plaques in the brain.
Do Microbes Trigger Alzheimer’s Disease?
Do Microbes Trigger Alzheimer’s Disease?
Jill U. Adams | Sep 1, 2017
The once fringe idea is gaining traction among the scientific community.
Infographic: Brain Infection and Alzheimer’s Disease Pathology
Infographic: Brain Infection and Alzheimer’s Disease Pathology
Jill U. Adams | Aug 31, 2017
Emerging evidence links bacterial or viral infection with the neuropathology of Alzheimer’s disease.
Toward Treating Alzheimer’s Disease with Brain Waves
Toward Treating Alzheimer’s Disease with Brain Waves
Ashley P. Taylor | Dec 7, 2016
In a mouse model, researchers mitigated three Alzheimer’s disease–associated symptoms by stimulating gamma waves with light.
Environmental Magnetite in the Human Brain
Environmental Magnetite in the Human Brain
Ashley P. Taylor | Sep 6, 2016
Mineral nanoparticles similar to those that have been associated with Alzheimer’s disease may enter the brain through the inhalation of polluted air.
Immunotherapy for Alzheimer’s Disease Shows Promise
Immunotherapy for Alzheimer’s Disease Shows Promise
Alison F. Takemura | Aug 31, 2016
Biogen’s aducanumab reduces amyloid-β plaques in a dose-dependent manner, according to interim results of a Phase 1b clinical trial.