3D illustration of a neuron with the cell body highlighted in pink to represent damage from an amyloid β plaque on its axons to the left. An enlarged plaque bundle is shown in the top left corner of the image, with the fibrils highlighted in pink and yellow.
| 5 min read
Dysregulated lipid metabolism in Alzheimer’s disease causes lipid buildup in microglia, reducing the immune cell’s ability to clear amyloid beta plaques.

amyloid beta plaques

Amyloid plaques on axons of neurons

The Misunderstood Proteins of Neurodegeneration

Ramified cells in a lilac background

Could Vitamin Supplementation Help Alzheimer’s Patients?

Bespectacled man wearing black shirt with arms folded looks at camera in front of lab cabinet

Neuropathologist John Trojanowski Dies at 75

An APP-knockout neuron (right) shows extended axonal and reduced dendritic growth compared with a normal mouse neuron (left). Scale bar 50 µm.

Amyloid Precursor Protein Linked to Brain Development Mechanisms

Illustration of neurons in white with myelin in blue

Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells

Colored artistic rendition of neurons and plaque buildup

Alzheimer’s Risk Gene Paradoxically Protects Against Memory Loss

Brain cells with electrical firing. 3D rendering.

Microglia as Therapeutic Targets in Neurodegenerative Diseases

blue and white sign for the entrance to the FDA that says U.S. Department of Health and Human Services Food and Drug Administration

Biogen’s Alzheimer’s Drug Gets FDA Approval, Mixed Reviews

A microscopy image of a mouse brain that shows the lymphatic system in bright purple and pink

Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice

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Image of an infant’s feet that are visible in a hospital incubator.

Record-Breaking DNA Sequencing Technology Could Transform Newborn Care

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A close-up image of a fly landing on a dessert

What Happens When a Fly Lands on Your Food? 

The World's Densest Bones

Multimedia

Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

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Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

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