analgesics
Synthetic Botox Treats Chronic Pain in Mice
Synthetic Botox Treats Chronic Pain in Mice
Abby Olena | Jul 18, 2018
Researchers silence pain neurons in the mouse spinal cord with injections of botulinum toxins modified to bind to the neurons’ receptors.
Sex Differences in Opioid Analgesia: A Complicated Picture
Sex Differences in Opioid Analgesia: A Complicated Picture
Catherine Offord | Dec 31, 2017
Researchers are beginning to tease apart the mechanisms underlying differences in how males and females respond to powerful painkillers.
Animal Analgesics
Animal Analgesics
The Scientist Staff | Dec 31, 2017
A cornucopia of toxins in the animal kingdom could provide inspiration for novel painkillers, but so far, effective drugs have proven elusive.
 
Novel Analgesics at a Snail’s Pace
Novel Analgesics at a Snail’s Pace
Bob Grant | Dec 31, 2017
Studying cone snail venom has yielded novel pain pathways, but the peptides that function as toxins are difficult to translate into drugs.
Mining Spider Toxins for Analgesic Clues
Mining Spider Toxins for Analgesic Clues
Catherine Offord | Dec 31, 2017
Arachnids harbor a plentiful array of molecules that target mammalian pain receptors.
Toxin from a Dangerous Fish Delicacy
Toxin from a Dangerous Fish Delicacy
Kerry Grens | Dec 31, 2017
In tiny doses, the pufferfish’s tetrodotoxin can be turned into a pain-relieving ion channel blocker.
Sourcing Painkillers from Scorpions’ Stings
Sourcing Painkillers from Scorpions’ Stings
Abby Olena | Dec 31, 2017
Compounds in the arachnids’ venom interact with ion channels to both cause and block pain.
Sea Anemone Toxin Could Treat Autoimmunity
Sea Anemone Toxin Could Treat Autoimmunity
Jef Akst | Dec 31, 2017
If successful, the treatments could alleviate patients’ pain by reducing inflammation.
Frog Skin Yields Potent Painkillers, but None Clinic Ready
Frog Skin Yields Potent Painkillers, but None Clinic Ready
Shawna Williams | Dec 31, 2017
Decades after their discovery by bioprospectors, amphibian-derived analgesics continue to attract scientific attention.
Snake Venoms Cause and Block Pain
Snake Venoms Cause and Block Pain
Kerry Grens | Dec 31, 2017
Painful snake bites may hold clues to developing analgesic drugs.