Researchers found that allegedly noncoding genetic material carries the instructions for many peptides that may help harness the immune system to fight cancer.

A team has engineered two stem cell lines into “synthetic T cells” that destroy breast cancer cells in vitro. 

At low doses, resveratrol enhanced human T-cell activity in vitro, while at high doses it interfered with cell signaling. 

Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.

The fluid motions of a T cell’s microvilli, scanning their environment for antigens, are captured in 3-D and in real time.

Neoantigens may serve as valuable targets for new immunotherapies.

Using proteomics methods to inform antigen selection