Illustration depicting DNA genetic engineering, purple background with white drawings of internal organs like liver, lung, kidney, brain, intestine, stomach and a red heart featuring two orange DNA helices being cut by labcoat-covered arms and hands, which are holding different instruments to cut the helices.
| 4 min read
Current CRISPR guide RNAs are designed based on European reference genomes, leading to false-negative results in cells from people with African ancestry.

bias

An outstretched hand holds a collection of prize medals in the sunlight

Analysis: Asian Researchers Scarce Among Biomedical Award Winners

Magazines and stethoscope

Q&A: Potential Partiality in Scientific Publishing

Anonymous person covering face with question mark

Revealing Peer Reviewer Identities Could Introduce Bias: Study

Puzzle of US and Chinese flags

Opinion: Policymakers’ Harmful Anti-China Obsession

Regina Vega-Trejo holding a net

Incest Isn’t Taboo in Nature: Study

animal behavior, animal cognition, reproducibility, replication, publishing, research integrity, animal research, experimental design, data reporting

STRANGE Framework Addresses Bias in Animal Behavior Research

High Risk of Bias in Early COVID-19 Studies: Meta-Analysis

Q&A, Genetics & Genomics, research bias, COVID-19, SARS-CoV-2, pandemic, coronavirus, big data

COVID-19 Research Biased Toward Only a Handful of Genes

Contributors

Trending

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

A close-up image of a fly landing on a dessert

What Happens When a Fly Lands on Your Food? 

Red and green small tomatoes. A new genetic engineering approach helped gene-edited plants grow faster.

Gene-Edited Crops Grow Faster with a Little Help from Bacteria

Image of an infant’s feet that are visible in a hospital incubator.

Record-Breaking DNA Sequencing Technology Could Transform Newborn Care

Multimedia

Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS

The Scientist Placeholder Image

Evosep Unveils Open Innovation Initiative to Expand Standardization in Proteomics

OGT logo

OGT expands MRD detection capabilities with new SureSeq Myeloid MRD Plus NGS Panel