Skip to main content

High Risk of Bias in Early COVID-19 Studies: Meta-Analysis

Few peer-reviewed clinical papers on the pandemic contained original data, and many of those that did had poor experimental design.

Written byMax Kozlov
| 5 min read

Register for free to listen to this article
Listen with Speechify
0:00
5:00

ABOVE: © ISTOCK.COM,
BRIANAJACKSON

As scientists led initial investigations into the novel coronavirus last winter and spring, journal publishers saw an enormous surge in COVID-19 publications. A study published January 4 in BMC Medical Research Methodology reports that the majority of early clinical studies on the pandemic lacked original data, and those that did were rushed and did not include the appropriate measures to reduce bias.

The researchers evaluated more than 10,000 COVID-19–related medical papers published in English or Chinese before May 2020. Among peer-reviewed papers, the researchers found that 56.1 percent were opinions that did not contain any new data. Original articles that included patient data represented only 9.6 percent of the peer-reviewed studies. The researchers then evaluated the quality of research of the original articles using validated tools to assess study design and concluded that 80 percent were at risk of bias, mainly because of few participants, short follow-up ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

  • Max is a science journalist from Boston. Though he studied cognitive neuroscience, he now prefers to write about brains rather than research them. Prior to writing for The Scientist as an editorial intern in late 2020 and early 2021, Max worked at the Museum of Science in Boston, where his favorite part of the job was dressing in a giant bee costume and teaching children about honeybees. He was also a AAAS Mass Media Fellow, where he worked as a science reporter for the St. Louis Post-Dispatch. Read more of his work at www.maxkozlov.com.

    View Full Profile

Related Topics

Related articles background image
August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

View this Issue
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi
Mapping Clonal Mosaicism in Aging Tissues

Mapping Clonal Mosaicism in Aging Tissues

Mission bio

Products

Sino Biological Logo

Sino Biological Launches SuperNuclease ® Pro with Free Trial Program

Sino Biological Logo

Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

Lucid Scientific logo
Conceptual image of ice and frost.

The VAULT100 PRO: Inside the most advanced Stirling Ultracold ULT freezer ever built.

Stirling Ultracold logo