A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind

Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

clinical trial design
Indian Study Shows No Survival Benefit of Plasma in COVID-19
Indian Study Shows No Survival Benefit of Plasma in COVID-19
Alakananda Dasgupta | Sep 15, 2020
A randomized controlled trial on the use of convalescent plasma therapy to treat coronavirus infections—the first in the world to be completed—yields disappointing results, but some doctors are not discouraged.
COVID-19 Convalescent Plasma Trials
COVID-19 Convalescent Plasma Trials
The Scientist Staff | Aug 18, 2020
UPenn’s Katharine Bar discusses ongoing clinical trials to explore the efficacy of treating patients with plasma from individuals who have recovered from an infection.
Two COVID-19 Clinical Trials Seek to Enroll Pregnant Women
Two COVID-19 Clinical Trials Seek to Enroll Pregnant Women
Jef Akst | Jul 20, 2020
Upon seeing pregnant women sick with COVID-19 at a University of Pennsylvania hospital, researchers there wrote trial protocols for blood transfusions to treat the disease that include expecting mothers.
Support for Vaccine Challenge Trials Gains Momentum
Support for Vaccine Challenge Trials Gains Momentum
Shawna Williams | May 11, 2020
The idea of deliberately infecting volunteers with SARS-CoV-2 has garnered significant attention as a potential avenue to speedier development, as the World Health Organization weighs in with recommendations.
The Latest Drug Trials for Coronavirus
The Latest Drug Trials for Coronavirus
Ashley Yeager | Feb 18, 2020
Under careful watch of the World Health Organization, doctors will test a range of COVID-19 therapies, including HIV and flu antivirals, blood plasma infusions, and traditional Chinese medicines.
A New Way to Establish Cause and Effect in Epidemiology?
A New Way to Establish Cause and Effect in Epidemiology?
Rachael Moeller Gorman | Jan 1, 2020
A technique called Mendelian randomization is overturning the conclusions of observational studies in public health. But researchers question whether the method can overcome its fundamental limitations.
Interactive: Biomarkers in Blood Provide a Window into the Brain
Interactive: Biomarkers in Blood Provide a Window into the Brain
Shawna Williams | Dec 1, 2019
A look at some of the circulating molecules that may indicate various Alzheimer’s pathologies and serve as the bases of noninvasive tests for the disease.
The Hunt for a Blood Test for Alzheimer’s Disease
The Hunt for a Blood Test for Alzheimer’s Disease
Shawna Williams | Dec 1, 2019
Researchers hope circulating biomarkers will enable earlier detection and better monitoring of the neurodegenerative disorder—and perhaps help usher in new treatments.
Industry Partners Extensively Involved in Trials They Fund
Industry Partners Extensively Involved in Trials They Fund
Catherine Offord | Oct 5, 2018
A new study suggests that sponsors downplay their influence when reporting trials carried out in collaboration with academic researchers.