Zebrafish with parts of nervous system in green.
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.
ABOVE: Marko Pende, Science Advances
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.

ABOVE: Marko Pende, Science Advances

bioethics

A photo of a skeleton on a black background
Ancient DNA Boom Underlines a Need for Ethical Frameworks
Amanda Heidt | Jan 27, 2022
The field of ancient DNA, which combines archaeology and anthropology with cutting-edge genetics, is requiring scientists to have frank conversations about when research is justified and who it benefits.
Multiple purple and pink renditions of stem cells appear as spherical clusters enveloped in translucent bubbles
Mammalian Embryos Might Not Need Primitive Streaks After All
Dan Robitzski | Dec 2, 2021
The primitive streak, a structure that emerges during mammalian and avian gastrulation, might be a byproduct rather than a landmark of the embryonic development process.
Great Minds Don't Think Alike
Book Excerpt from Great Minds Don't Think Alike
Marcelo Gleiser | Dec 1, 2021
In the introduction, editor Marcelo Gleiser establishes the need for dialogue across the science-humanities divide in academia.
Great Minds Don't Think Alike
Opinion: Bridging the Intellectual Divide
Marcelo Gleiser | Dec 1, 2021
To solve modern problems, we must integrate the sciences and the humanities and think across these traditionally disparate disciplines.
Hong Kong skyline with a pink sky in the background
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.
Opinion: How Biomedicine Could Transform Human Reproduction
Henry T. Greely | Aug 1, 2021
CRISPR and other innovations are likely to open up a wealth of new options for how people have children.
cartoon showing a hand taking a tool to a double-helix of DNA to represent gene editing
WHO Releases New Recommendations on Human Genome Editing
Annie Melchor | Jul 12, 2021
The guidance comes after two years of consulting with hundreds of stakeholders, including indigenous peoples, religious leaders, patient groups, and scientists.
photo of a researcher looking in a microscope fertilising an egg via intracytoplasmic sperm injection.
Human Stem Cell Research Guidelines Updated
Ruth Williams | May 26, 2021
Removal of the 14-day limit for culturing human embryos is one of the main changes in the revised recommendations from the International Society for Stem Cell Research.
fetal cells, fetal stem cells, policy, Biden administration, Trump administration, NIH
NIH Reverses Limits on Human Fetal Tissue Research
Amanda Heidt | Apr 19, 2021
A new ruling removes the requirement that grants and proposals using the material receive approval from an ethical review board, reverting to the process in place before 2019.
ethics, bioethics, brain organoid, chimera, cell transplant, Q&A, report, NIH, NAS, neuroscience, Techniques, disease & medicine, immunology, psychiatric conditions
New Report Dissects Ethics of Emerging Human Brain Cell Models
Amanda Heidt | Apr 12, 2021
The National Academies’ report touches on ethical issues raised by new technologies such as brain organoids and human-animal chimeras, and suggests that current regulatory oversight is sufficient.
Opinion: Facing Assumptions About the Duality of Human and Animal
Melanie Challenger | Apr 1, 2021
Since Darwin published his landmark work on natural selection, we’ve understood that we’re animals. But that doesn’t mean we really believe it.
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
Jef Akst | Oct 8, 2020
Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.
human-animal chimeric embryo, chimera, animal studies, pigs, organ transplant, induced pluripotent stem cells, survey, attitudes, public support
Majority of Respondents Support Chimeric Animal Research: Survey
Amanda Heidt | Oct 1, 2020
Almost 60 percent of people in a new study on attitudes in the US felt comfortable using animals to grow human organs from induced pluripotent stem cells.
COVID-19, SARS-CoV-2, coronavirus, pandemic, Russia, vaccine, clinical trial, data, ethics, adenovirus, spike protein, Lancet
Scientists Voice Concerns over Russian COVID-19 Vaccine Study
Amanda Heidt | Sep 11, 2020
Almost 40 scientists have signed an open letter, citing odd patterns in the data and a lack of transparency after authors withheld the full data.
Panel Lays Out Guidelines for CRISPR-Edited Human Embryos
Lisa Winter | Sep 4, 2020
The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.
vaccine, Covid-19, coronavirus, SARS-CoV-2, pandemic, self experimentation, polio, poliovirus, yellow fever, Jonas Salk, Joseph Goldberger, George Church
Self-Experimentation in the Time of COVID-19
Amanda Heidt | Aug 6, 2020
Scientists are taking their own vaccines, an ethically murky practice that has a long and sometimes celebrated history in medicine.
Most Members of Federal Fetal Tissue Ethics Panel Oppose Abortion
Lisa Winter | Aug 3, 2020
The members of a new advisory board to the NIH met for the first time and will weigh in on federal funding for grants that rely on donated tissue from abortions.
a gloved hand holds a vial labeled "SARS-CoV-2 vaccine, COVID-19"
Support for Vaccine Challenge Trials Gains Momentum
Shawna Williams | May 11, 2020
The idea of deliberately infecting volunteers with SARS-CoV-2 has garnered significant attention as a potential avenue to speedier development, as the World Health Organization weighs in with recommendations.
antibody test coronavirus covid-19 sars-cov-2 immunity privacy confidentiality ethics bioethics public safety health
Opinion: Public Health Trumps Privacy in a Pandemic
John D. Loike, Ruth L. Fischbach | Apr 16, 2020
If governments were to use SARS-CoV-2 antibody tests to manage who can re-enter the workplace, society must accept a sacrifice of privacy.