Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

Upon seeing pregnant women sick with COVID-19 at a University of Pennsylvania hospital, researchers there wrote trial protocols for blood transfusions to treat the disease that include expecting mothers.

Two clinical trial participants—one with β-thalassemia and one with sickle cell disease—appeared to benefit from the gene-editing treatments with minimal side effects, according to the companies.

YODA, a program facilitated by Yale University researchers, has successfully distributed clinical trial records from Johnson & Johnson and Medtronic to external researchers since 2013.

OpenTrials.net seeks to increase transparency and make clinical research more accessible to the public.

Thoughts on how to redesign clinical trials for traumatic brain injury

Scientists identify a human leukocyte antigen gene linked to immune protection from HIV following vaccination.

Enrolling the right patient population could be key to a successful clinical trial.