Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Participant’s Diagnosis Halts Gene Therapy Clinical Trial

The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.

The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.

clinical trial participants
Gene Therapy Continues to Benefit Kids with Immunodeficiency
Gene Therapy Continues to Benefit Kids with Immunodeficiency
Jef Akst | May 12, 2021
Four dozen children with severe combined immunodeficiency (SCID) who received a corrective gene carried by a virus have working immune systems two to three years later, according to three independent clinical trials.
Pandemic Accelerates Trend Toward Remote Clinical Trials
Pandemic Accelerates Trend Toward Remote Clinical Trials
Jef Akst | May 1, 2021
Now more than ever before, recruiting patients for a research study doesn’t have to mean getting them to leave their homes.
Johnson & Johnson Pauses COVID-19 Vaccine Trials
Johnson & Johnson Pauses COVID-19 Vaccine Trials
Amanda Heidt | Oct 13, 2020
The company voluntarily paused its studies, including one in Phase 3, after an unexplained illness in a patient.
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
Jef Akst | Oct 8, 2020
Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.
Two COVID-19 Clinical Trials Seek to Enroll Pregnant Women
Two COVID-19 Clinical Trials Seek to Enroll Pregnant Women
Jef Akst | Jul 20, 2020
Upon seeing pregnant women sick with COVID-19 at a University of Pennsylvania hospital, researchers there wrote trial protocols for blood transfusions to treat the disease that include expecting mothers.
Early Results Are Positive for Experimental CRISPR Therapies
Early Results Are Positive for Experimental CRISPR Therapies
Jef Akst | Nov 19, 2019
Two clinical trial participants—one with β-thalassemia and one with sickle cell disease—appeared to benefit from the gene-editing treatments with minimal side effects, according to the companies.
Data Sharing in Action: When Drug Companies Open Their Trial Vaults
Data Sharing in Action: When Drug Companies Open Their Trial Vaults
Abby Olena | Dec 3, 2018
YODA, a program facilitated by Yale University researchers, has successfully distributed clinical trial records from Johnson & Johnson and Medtronic to external researchers since 2013.
Clinical Trial Database Launches
Clinical Trial Database Launches
Bob Grant | Oct 12, 2016
OpenTrials.net seeks to increase transparency and make clinical research more accessible to the public.
Opinion: Why Most TBI Studies Fail
Opinion: Why Most TBI Studies Fail
Donald Stein | Feb 24, 2016
Thoughts on how to redesign clinical trials for traumatic brain injury
Why an HIV Vax Only Works for Some
Why an HIV Vax Only Works for Some
Anna Azvolinsky | Jul 15, 2015
Scientists identify a human leukocyte antigen gene linked to immune protection from HIV following vaccination.
Clinical Matchmaker
Clinical Matchmaker
Kate Yandell | Jun 1, 2015
Enrolling the right patient population could be key to a successful clinical trial.