An illustration of James Trosko, now a cancer biologist at Michigan State University, with long brown hair and close beard wearing a white lab coat on the right of the image. He is holding a cell culture plate and looking at it inquiringly. On the left is a call out showing where, in the cell culture dish, pink, irregular cells are sitting close to one another. The background is an image of these same cells in a green overlay.
| 2 min read
James Trosko thought he would find out how one molecule affected DNA repair. Instead, he chanced upon a non-mutagenic start to cancer.

DNA repair

Optimizing Gene Editing Experimental Design

Optimizing Gene Editing Experimental Design

Optimizing Gene Editing Experimental Design

Optimizing Gene Editing Experimental Design

Blue DNA double helix breaking apart.

Keeping Telomeres in Their Places

Crystalline ball-and-stick model representation of a molecular structure.

Prioritizing PARylation in DNA Damage and Repair

A mouse embryo in which the head, spine, and limb buds are visible.

Illuminating Craniofacial Development

A DNA strand in yellow and blue is surrounded by a poly (ADP-ribose) polymerase (PARP) protein.

Therapeutic Development for Breast Cancer and Beyond

A younger-looking mouse next to an older-looking one

Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

illustration of DNA strands

Mitochondrial DNA Sneaks into Nuclear Genome

Trending

Kirsty Wright is searching for evidence in a missing persons investigation. She is wearing a blue shirt and glasses. Behind her is dense vegetation and police procedural tape.

How a Forensic Biologist Exposed a DNA Lab Scandal That Shook Australia

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

Hands holding an older woman’s hands.

One Gene Influences 75 Percent of Alzheimer’s Disease Cases

A picture of Rohita Roy, a postdoc at Stanford University.

Postdoc Portrait: Rohita Roy

Multimedia

The Scientist Placeholder Image

From Data to Discovery: Omics in Therapeutic Innovation

The Scientist Placeholder Image

Exploring Organoids for Disease Modeling Research

February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies