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A younger-looking mouse next to an older-looking one
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

DNA repair
illustration of DNA strands
Mitochondrial DNA Sneaks into Nuclear Genome
Holly Barker | Oct 17, 2022 | 3 min read
Genetic material pilfered from mitochondria may seal cracks in our genetic code, a study suggests.
illustration of a broken DNA strand
DNA Damage Makes Zebrafish Sleepy
Sophie Fessl, PhD | Nov 18, 2021 | 4 min read
Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.
Researchers target E. coli in the mouse gut
Modifying the Microbiome In Vivo, One Species or Gene at a Time
Niki Spahich, PhD | 4 min read
To manipulate the microbiome, researchers engineered a CRISPR delivery system that precisely targets bacteria in the mouse gut.
screen shot from a microscopy video of a green cell exiting a red cell and then entering two other green cells in sequence as a yellow arrow follows the original green cell
Cancer Cells Parasitize Other Ones to Survive: Study
Marcus A. Banks | May 13, 2021 | 3 min read
Tumor cells missing a critical protein enter neighboring cells to sap their nutrients, then exit those hosts as intact cells, possibly primed to metastasize. Other scholars say it’s too early to know this for sure.
Mouse club cells
Image of the Day: Resilient Lung Cells
Nicoletta Lanese | Aug 1, 2019 | 1 min read
A specific type of lung cell withstands flu infection by doubling down on DNA repair.
Laptop displays CRISPR poster.
The Next Generation of CRISPR-Cas Systems
Nathan Ni, PhD | 1 min read
Researchers reinvent genome editing with new CRISPR-Cas systems.
Sleep Is Critical for the Zebrafish Brain to Repair DNA Damage
Catherine Offord | Mar 6, 2019 | 2 min read
Neurons can only efficiently fix genetic injuries when the animals are asleep.
literature infographic dna repair
Without This Enzyme, Insertions Thrive in the Yeast Genome
Katarina Zimmer | Mar 1, 2019 | 3 min read
A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.
Direct Capture of Guide RNAs Enables Scalable and Combinatorial Single-Cell CRISPR Screens
The Scientist Creative Services Team | 1 min read
10x Genomics invites you to join them for an educational webinar.
the literature infographic dna repairing
Infographic: How Stray DNA Can Land in Double-Strand Breaks
Katarina Zimmer | Mar 1, 2019 | 1 min read
A study on yeast illuminates how insertions may occur.
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
Vicki Brower | Apr 1, 2018 | 9 min read
With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.
Alcohol Damages Mouse DNA
Jef Akst | Jan 3, 2018 | 1 min read
A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Catherine Offord | Oct 25, 2017 | 8 min read
With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.
Damage Patroller
Anna Azvolinsky | Oct 1, 2017 | 9 min read
Stephen Elledge has built a career studying how eukaryotic cells maintain genomic integrity.
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017 | 10+ min read
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Infographic: The Various Forms of Methylated DNA
Skirmantas Kriaucionis | Aug 31, 2017 | 1 min read
To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.
CRISPR: No Cutting Required
Anna Azvolinsky | Aug 4, 2016 | 3 min read
Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide. 
Advances in Genome Editing
Catherine Offord | Apr 20, 2016 | 4 min read
Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.
New Way to Edit Genes
Jef Akst | Oct 1, 2015 | 1 min read
Researchers develop a more-efficient method for rewriting DNA that could hold therapeutic value for HIV and other diseases.
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