illustration of a broken DNA strand
DNA Damage Makes Zebrafish Sleepy
Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.
ABOVE: © ISTOCK.COM, TOMACCO
DNA Damage Makes Zebrafish Sleepy
DNA Damage Makes Zebrafish Sleepy

Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.

Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.

ABOVE: © ISTOCK.COM, TOMACCO

DNA repair

screen shot from a microscopy video of a green cell exiting a red cell and then entering two other green cells in sequence as a yellow arrow follows the original green cell
Cancer Cells Parasitize Other Ones to Survive: Study
Marcus A. Banks | May 13, 2021
Tumor cells missing a critical protein enter neighboring cells to sap their nutrients, then exit those hosts as intact cells, possibly primed to metastasize. Other scholars say it’s too early to know this for sure.
Mouse club cells
Image of the Day: Resilient Lung Cells
Nicoletta Lanese | Aug 1, 2019
A specific type of lung cell withstands flu infection by doubling down on DNA repair.
Researchers target E. coli in the mouse gut
Modifying the Microbiome In Vivo, One Species or Gene at a Time
Niki Spahich, PhD | Feb 16, 2022
To manipulate the microbiome, researchers engineered a CRISPR delivery system that precisely targets bacteria in the mouse gut.
Sleep Is Critical for the Zebrafish Brain to Repair DNA Damage
Catherine Offord | Mar 6, 2019
Neurons can only efficiently fix genetic injuries when the animals are asleep.
literature infographic dna repair
Without This Enzyme, Insertions Thrive in the Yeast Genome
Katarina Zimmer | Mar 1, 2019
A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.
Laptop displays CRISPR poster.
The Next Generation of CRISPR-Cas Systems
Nathan Ni, PhD | Feb 4, 2021
Researchers reinvent genome editing with new CRISPR-Cas systems.
the literature infographic dna repairing
Infographic: How Stray DNA Can Land in Double-Strand Breaks
Katarina Zimmer | Mar 1, 2019
A study on yeast illuminates how insertions may occur.
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
Vicki Brower | Apr 1, 2018
With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.
Direct Capture of Guide RNAs Enables Scalable and Combinatorial Single-Cell CRISPR Screens
The Scientist Creative Services Team | Jun 25, 2020
10x Genomics invites you to join them for an educational webinar.
Alcohol Damages Mouse DNA
Jef Akst | Jan 3, 2018
A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Catherine Offord | Oct 25, 2017
With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.
Damage Patroller
Anna Azvolinsky | Oct 1, 2017
Stephen Elledge has built a career studying how eukaryotic cells maintain genomic integrity.
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Infographic: The Various Forms of Methylated DNA
Skirmantas Kriaucionis | Aug 31, 2017
To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.
CRISPR: No Cutting Required
Anna Azvolinsky | Aug 4, 2016
Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide. 
Advances in Genome Editing
Catherine Offord | Apr 20, 2016
Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.
New Way to Edit Genes
Jef Akst | Oct 1, 2015
Researchers develop a more-efficient method for rewriting DNA that could hold therapeutic value for HIV and other diseases.
Age-Old Questions
Mary Beth Aberlin | Mar 1, 2015
How do we age, and can we slow it down?
Wrangling Retrotransposons
Andrei Seluanov, Michael Van Meter, Vera Gorbunova | Mar 1, 2015
These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.