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| 4 min read
Large-bodied animals across the tree of life have evolved unique ways to combat cancer which could inspire novel therapeutic strategies.

DNA repair

Optimizing Gene Editing Experimental Design

Optimizing Gene Editing Experimental Design

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Blue DNA double helix breaking apart.

Keeping Telomeres in Their Places

Crystalline ball-and-stick model representation of a molecular structure.

Prioritizing PARylation in DNA Damage and Repair

A mouse embryo in which the head, spine, and limb buds are visible.

Illuminating Craniofacial Development

A DNA strand in yellow and blue is surrounded by a poly (ADP-ribose) polymerase (PARP) protein.

Therapeutic Development for Breast Cancer and Beyond

A younger-looking mouse next to an older-looking one

Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

illustration of DNA strands

Mitochondrial DNA Sneaks into Nuclear Genome

Researchers target E. coli in the mouse gut

Modifying the Microbiome In Vivo, One Species or Gene at a Time

Promoting homology-directed repair (HDR) in CRISPR applications

Improving CRISPR Homology-Directed Repair (HDR) Rates

illustration of a broken DNA strand

DNA Damage Makes Zebrafish Sleepy

screen shot from a microscopy video of a green cell exiting a red cell and then entering two other green cells in sequence as a yellow arrow follows the original green cell

Cancer Cells Parasitize Other Ones to Survive: Study

Laptop displays CRISPR poster.

The Next Generation of CRISPR-Cas Systems

Direct Capture of Guide RNAs Enables Scalable and Combinatorial Single-Cell CRISPR Screens

Mouse club cells

Image of the Day: Resilient Lung Cells

Sleep Is Critical for the Zebrafish Brain to Repair DNA Damage

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Without This Enzyme, Insertions Thrive in the Yeast Genome

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Infographic: How Stray DNA Can Land in Double-Strand Breaks

PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers

Alcohol Damages Mouse DNA

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An illustration of red-colored meat products against a peach background.

The Alpha-Gal Syndrome Story: How Researchers Traced a Red-Meat Allergy to Ticks

Many spiral-shaped orange Borrelia bacteria.

Fragments of Lyme Disease Bacteria Linked to Liver Dysfunction

An obese mouse on the left compared with normal control on right.

How Cysteine Depletion Drives Cells to Burn Fat 

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

Multimedia

Conceptual image of automated liquid handling showing multiple pipette tips dispensing blue fluid into a multi-well dish.

Advances in Automated RNA Library Preparation

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Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

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July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

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Genome Modeling and Design: From the Molecular to Genome Scale

Genome Modeling and Design: From the Molecular to Genome Scale

Twist Bio 
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

DNA and pills, conceptual illustration of the relationship between genetics and therapeutic development

Multiplexing PCR Technologies for Biopharmaceutical Research

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Discover how to streamline tumor-infiltrating lymphocyte production.

Producing Tumor-infiltrating Lymphocyte Therapeutics

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Products

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Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA

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Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

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Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

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Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery