DNA repair
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers
Vicki Brower | Apr 1, 2018
With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.
Alcohol Damages Mouse DNA
Alcohol Damages Mouse DNA
Jef Akst | Jan 3, 2018
A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Catherine Offord | Oct 25, 2017
With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.
Damage Patroller
Damage Patroller
Anna Azvolinsky | Oct 1, 2017
Stephen Elledge has built a career studying how eukaryotic cells maintain genomic integrity.
The Role of DNA Base Modifications
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Infographic: The Various Forms of Methylated DNA
Infographic: The Various Forms of Methylated DNA
Skirmantas Kriaucionis | Aug 31, 2017
To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.
CRISPR: No Cutting Required
CRISPR: No Cutting Required
Anna Azvolinsky | Aug 4, 2016
Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide. 
Advances in Genome Editing
Advances in Genome Editing
Catherine Offord | Apr 20, 2016
Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.
New Way to Edit Genes
New Way to Edit Genes
Jef Akst | Oct 1, 2015
Researchers develop a more-efficient method for rewriting DNA that could hold therapeutic value for HIV and other diseases.
Age-Old Questions
Age-Old Questions
Mary Beth Aberlin | Mar 1, 2015
How do we age, and can we slow it down?