DNA repair

Tumor cells missing a critical protein enter neighboring cells to sap their nutrients, then exit those hosts as intact cells, possibly primed to metastasize. Other scholars say it’s too early to know this for sure.

A specific type of lung cell withstands flu infection by doubling down on DNA repair.

Neurons can only efficiently fix genetic injuries when the animals are asleep.

A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.

A study on yeast illuminates how insertions may occur.

With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.

With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.

Stephen Elledge has built a career studying how eukaryotic cells maintain genomic integrity.

Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.

To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.

Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide. 

Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.

Researchers develop a more-efficient method for rewriting DNA that could hold therapeutic value for HIV and other diseases.

How do we age, and can we slow it down?

These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.