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DNA repair

Mitochondrial DNA Sneaks into Nuclear Genome

Holly Barker, PhD | Oct 17, 2022 | 3 min read

Genetic material pilfered from mitochondria may seal cracks in our genetic code, a study suggests.

Researchers target E. coli in the mouse gut

Modifying the Microbiome In Vivo, One Species or Gene at a Time

Niki Spahich, PhD | Feb 16, 2022 | 4 min read

To manipulate the microbiome, researchers engineered a CRISPR delivery system that precisely targets bacteria in the mouse gut.

The Next Generation of CRISPR-Cas Systems

Nathan Ni, PhD | 1 min read

Researchers reinvent genome editing with new CRISPR-Cas systems.

DNA Damage Makes Zebrafish Sleepy

Sophie Fessl, PhD | Nov 18, 2021 | 4 min read

Buildup of a DNA-repair protein in brain cells spurs shut-eye in the fish, a study finds, and similar results in mice suggest the mechanism is widespread in animals.

screen shot from a microscopy video of a green cell exiting a red cell and then entering two other green cells in sequence as a yellow arrow follows the original green cell

Cancer Cells Parasitize Other Ones to Survive: Study

Marcus A. Banks | May 13, 2021 | 3 min read

Tumor cells missing a critical protein enter neighboring cells to sap their nutrients, then exit those hosts as intact cells, possibly primed to metastasize. Other scholars say it’s too early to know this for sure.

Direct Capture of Guide RNAs Enables Scalable and Combinatorial Single-Cell CRISPR Screens

The Scientist’s Creative Services Team | 1 min read

10x Genomics invites you to join them for an educational webinar.

Image of the Day: Resilient Lung Cells

Nicoletta Lanese | Aug 1, 2019 | 1 min read

A specific type of lung cell withstands flu infection by doubling down on DNA repair.

Sleep Is Critical for the Zebrafish Brain to Repair DNA Damage

Catherine Offord | Mar 6, 2019 | 2 min read

Neurons can only efficiently fix genetic injuries when the animals are asleep.

Without This Enzyme, Insertions Thrive in the Yeast Genome

Katarina Zimmer | Mar 1, 2019 | 3 min read

A study underscores the importance of Dna2 in maintaining the integrity of the genetic code.

the literature infographic dna repairing

Infographic: How Stray DNA Can Land in Double-Strand Breaks

Katarina Zimmer | Mar 1, 2019 | 1 min read

A study on yeast illuminates how insertions may occur.

PARP Inhibitors Are Improving the Outlook of Hard-to-Treat Cancers

Vicki Brower | Apr 1, 2018 | 9 min read

With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.

Alcohol Damages Mouse DNA

Jef Akst | Jan 3, 2018 | 1 min read

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.

Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine

Catherine Offord | Oct 25, 2017 | 8 min read

With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.

Damage Patroller

Anna Azvolinsky | Oct 1, 2017 | 9 min read

Stephen Elledge has built a career studying how eukaryotic cells maintain genomic integrity.

The Role of DNA Base Modifications

Skirmantas Kriaucionis | Sep 1, 2017 | 10+ min read

Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.

Infographic: The Various Forms of Methylated DNA

Skirmantas Kriaucionis | Aug 31, 2017 | 1 min read

To expand the basic nucleotide alphabet, many species modify their DNA with epigenetic marks.

CRISPR: No Cutting Required

Anna Azvolinsky | Aug 4, 2016 | 3 min read

Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide.