DNA replication
![Image of three chromosomes "trees" with the highlighted section displaying telomeres shortening over time as “falling leaves”.](https://cdn.the-scientist.com/assets/articleNo/71852/aImg/52981/telomeres-800x560-t.jpg "Image of three chromosomes "trees" with the highlighted section displaying telomeres shortening over time as “falling leaves”.")
Chromosome Ends in Double Jeopardy
Laura Tran, PhD | May 16, 2024 | 4 min read
Researchers have finally uncovered the other half of the end-replication problem at the lagging strand.
Prioritizing PARylation in DNA Damage and Repair
The Scientist Staff | Apr 1, 2024 | 2 min read
Measuring cellular poly ADP-ribosylation can unlock new anticancer strategies and approaches.
DNA Methylation Influences Replication and Genome Organization
Abby Olena, PhD | Sep 22, 2021 | 3 min read
A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.
DNA Damage Linked to Brain Overgrowth in Autism
Abby Olena, PhD | Feb 5, 2020 | 4 min read
Cell lines from individuals with macrocephalic autism spectrum disorder have an increased number of double-strand breaks in the DNA of long neural genes.
Cancer Researcher, Former AACR President Dies
Kerry Grens | Nov 13, 2017 | 2 min read
Donald Coffey, a longtime professor at Johns Hopkins University, discovered the nuclear matrix within cells and its role in DNA replication.
The Role of DNA Base Modifications
Skirmantas Kriaucionis | Sep 1, 2017 | 10+ min read
Researchers are just beginning to scratch the surface of how several newly recognized epigenetic changes function in the genome.
Telomere Basics
Rodrigo Calado and Neal Young | May 1, 2012 | 1 min read
Telomeres are repetitive, noncoding sequences that cap the ends of linear chromosomes. They consist of hexameric nucleotide sequences (TTAGGG in humans) repeated hundreds to thousands of times.