Study Points to Novel Role for Microglia in Down Syndrome
Study Points to Novel Role for Microglia in Down Syndrome
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.
Study Points to Novel Role for Microglia in Down Syndrome
Study Points to Novel Role for Microglia in Down Syndrome

Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.

Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.

Down Syndrome
Scientists Grapple with US Restrictions on Fetal Tissue Research
Scientists Grapple with US Restrictions on Fetal Tissue Research
Diana Kwon | Mar 2, 2020
The Trump administration’s changes to policy involving material donated from abortions have led scientists to adjust their research projects or seek alternative sources of funding.
Scientists Destroy Entire Chromosome with CRISPR
Scientists Destroy Entire Chromosome with CRISPR
Kerry Grens | Aug 1, 2017
Multiple DNA breaks at either the centromere or the long arm of the mouse Y chromosome cause it to fragment and disappear.
More Mini Brains
More Mini Brains
Jef Akst | Feb 17, 2016
Simple versions of brain organoids could serve as new models for testing the effects of drugs, researchers reported at this year’s AAAS meeting. 
Probing Down Syndrome with Mini Brains
Probing Down Syndrome with Mini Brains
Bob Grant | Oct 20, 2015
Researchers create cerebral organoids using induced pluripotent stem cells from patient skin cells and characterize protein-expression changes linked to cognitive impairment.
Week in Review: April 14–18
Week in Review: April 14–18
Tracy Vence | Apr 18, 2014
Genome-wide effects of trisomy 21; RNA-based signs of transgenerational stress; depression and resilience; a call to overhaul US biomedical research system
Trisomy 21 Effects Seen Genome-wide
Trisomy 21 Effects Seen Genome-wide
Rina Shaikh-Lesko | Apr 16, 2014
The extra chromosome behind Down’s syndrome can impact transcriptional regulation beyond chromosome 21, a study finds.
Should Standard Prenatal Screening be Scrapped?
Should Standard Prenatal Screening be Scrapped?
Bob Grant | Feb 28, 2014
Researchers suggest that a new prenatal DNA test should become the new standard to detect Down syndrome in fetuses.
New Down Syndrome Protein Found
New Down Syndrome Protein Found
Edyta Zielinska | Mar 26, 2013
Researchers identify a protein involved in the chromosomal disorder that could explain its characteristic learning deficits.
Year of the Fetus
Year of the Fetus
Beth Marie Mole | Dec 18, 2012
2012 saw the birth of a handful of non-invasive genetic prenatal tests, but the young industry faces growing pains as legal and ethical questions loom.