a smiling woman standing between a much taller man and woman
Protein Size Matters
A study probes how genetic duplications that can swell protein length influence human traits such as height and kidney function.
ABOVE: ISTOCK.COM, LittleCityLifestylePhotography
Protein Size Matters
Protein Size Matters

A study probes how genetic duplications that can swell protein length influence human traits such as height and kidney function.

A study probes how genetic duplications that can swell protein length influence human traits such as height and kidney function.

ABOVE: ISTOCK.COM, LittleCityLifestylePhotography
gene silencing
Infographic: How Some X-Chromosome Genes Escape Inactivation
Amber Dance | Mar 1, 2020
About one-quarter of the hundreds of genes on the inactivated X chromosome in XX cells manage to escape that silencing, at least some of the time.
Genes that Escape Silencing on the Second X Chromosome May Drive Disease
Amber Dance | Mar 1, 2020
When X-linked genes evade silencing on the “inactive” chromosome in XX cells, some protect women from diseases such as cancer, but others seem to promote conditions such as autoimmunity.
Oded Rechavi Studies the RNA Nematodes Pass to Their Offspring
Emily Makowski | Jan 13, 2020
The Tel Aviv University researcher is interested in how the macromolecules affect the health and behavior of successive generations of worms.
Prominent Epigeneticist Dies
Bob Grant | Mar 7, 2017
The National Cancer Institute’s Amar Klar uncovered many of the intricacies of gene silencing and other heritable epigenetic alterations.
Methylation Maestro
Anna Azvolinsky | Jan 1, 2017
After initially discovering that DNA methylation represses transcription, Howard Cedar continues to explore how the epigenetic mark regulates gene expression.
Hidden Menace
John Frater, Genevieve Martin, Matthew Pace | May 1, 2015
Curing HIV means finding and eradicating viruses still lurking in the shadows.
Hide and Seek
The Scientist Staff | Apr 30, 2015
Oxford researcher John Frater explains the strategy of targeting viral reservoirs to beat HIV.
One Gene, Two Mutations
Tracy Vence | Nov 5, 2013
Knocking down a single gene spurs pronounced secondary effects in the yeast genome.
Gene Silencing Is Golden
Carina Storrs | Aug 1, 2013
A beginner’s how-to on RNAi screening in mammalian cells
Dynamic Delivery
Ruth Williams | Jul 1, 2012
Microscopic sponges made entirely of RNA enable efficient gene silencing.
Delivering Silence
Sabrina Richards | Mar 1, 2012
Using RNA viruses to silence genes could optimize tissue targeting while reducing toxicity.
Unsilencing a Gene
Tia Ghose | Dec 21, 2011
Scientists have found a way to reactivate a gene in mice that is silenced in a neurodevelopmental disorder called Angelman syndrome.