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| 3 min read
From nematodes to the clinic, RNAi has transformed biological research and delivered gene-silencing therapies for high cholesterol and rare genetic diseases.

gene silencing

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The Promise of RNAi Therapeutics for Cardiovascular Disease Treatment

Two cells on a purple background. Two mechanisms of gene silencing are shown in the cell on the left, while a double-strand break in a DNA region is shown in the cell on the right.

What’s the Difference Between Gene Knockdown and Gene Knockout?

Blue 3D illustration of X-shaped chromosomes

X Chromosome Silenced in Some Cancers in Males

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Protein Size Matters

Infographic: How Some X-Chromosome Genes Escape Inactivation

Genes that Escape Silencing on the Second X Chromosome May Drive Disease

Oded Rechavi Studies the RNA Nematodes Pass to Their Offspring

Prominent Epigeneticist Dies

Methylation Maestro

Trending

A drawing of men and women holding boxes, resigning en mass from their jobs as editors.

Editors Mass Resign from Elsevier Journal After Editor-in-Chief Let Go

A team of cartoon scientists studying a giant pancreas.

Prolonged GLP-1 Exposure Remodels Gene Expression in the Pancreas by Flipping a Molecular Switch

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Cockroach Milk Proteins Churn Out an Ig Nobel Win

In the TS 40th Anniversary template, Sarkis Mazmanian smiles in a black and white headshot photo on the left. In a photo on the right, he stands in front of a large image of a cross-section of the brain. He wears a navy jacket, a white shirt, and glasses.

Then and Now: Sarkis Mazmanian Finds Gut-Brain Links to Parkinson’s Disease

Multimedia

Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

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Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

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The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

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Essential Genes Are Dominantly Activated by Single Transcription Factors

Essential Genes Are Dominantly Activated by Single Transcription Factors

EpiCypher Logo
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Engineering CAR-Neutrophils In Vivo to Target Glioblastoma

Miltenyi
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad

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The ASSIST PLUS pipetting robot for affordable workflow automation

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CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

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Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays