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A CRISPR-Cas9 enzyme (orange) cutting a DNA strand (blue)
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

Human gene editing
Hong Kong skyline with a pink sky in the background
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021 | 9 min read
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.
Opinion: How Biomedicine Could Transform Human Reproduction
Henry T. Greely | Aug 1, 2021 | 3 min read
CRISPR and other innovations are likely to open up a wealth of new options for how people have children.
cartoon showing a hand taking a tool to a double-helix of DNA to represent gene editing
WHO Releases New Recommendations on Human Genome Editing
Annie Melchor | Jul 12, 2021 | 3 min read
The guidance comes after two years of consulting with hundreds of stakeholders, including indigenous peoples, religious leaders, patient groups, and scientists.
Panel Lays Out Guidelines for CRISPR-Edited Human Embryos
Lisa Winter | Sep 4, 2020 | 2 min read
The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.
China Sentences Gene-Editing Scientist to Three Years in Jail
Emily Makowski | Dec 30, 2019 | 2 min read
The modification of three babies’ genes by He Jiankui drew widespread criticism from scientists.
Deafness Gene GJB2 Edited in Human Eggs
Emily Makowski | Oct 18, 2019 | 2 min read
The research, led by Russian biologist Denis Rebrikov, has not led to the birth of gene-edited babies—yet.
Error in Study Linking HIV Resistance Gene to Increased Mortality
Emily Makowski | Sep 30, 2019 | 2 min read
The authors have requested a retraction of a paper that found people with the CCR5 Δ32 variant are more likely to die sooner.
crispr baby he jiankui gene editing genome fertility clinic emails
Fertility Clinics Sought Advice from Scientist Who CRISPRed Babies
Chia-Yi Hou | May 29, 2019 | 1 min read
Emails reveal that a facility in Dubai and others have asked geneticist He Jiankui for help in gene-editing embryos.
an illustration of T cells attacking a cancer cell
Two Patients Treated with CRISPRed Cells in Immunotherapy Trial
Shawna Williams | Apr 16, 2019 | 1 min read
One person with multiple myeloma and one with sarcoma are the first so far to receive the genetically engineered T cells in the study.
Scientists Push for a Moratorium on Human Germline Editing
Ashley Yeager | Mar 13, 2019 | 3 min read
After the reported birth of CRISPRed babies in China, experts want to take time to consider the scientific, social, ethical, and philosophical consequences of editing heritable human DNA.
China Proposes New Gene-Editing Regulations
Jef Akst | Feb 27, 2019 | 2 min read
After the controversy of a Chinese scientist who was involved in editing the genomes of twin girls, the country puts forth tighter guidelines.
Preliminary Results Point to Success of In Vivo Gene Editing
Carolyn Wilke | Feb 12, 2019 | 2 min read
Two studies show signs that the introduced DNA is functioning, but it’s too early to know if patients actually benefit.
a rooftop and tower at Stanford University
The US Scientists Who Knew About CRISPRed Babies
Shawna Williams | Jan 29, 2019 | 3 min read
Multiple researchers were aware of He Jiankui’s clinical trial before the news became public in November.
Genome Editing on Board
Bob Grant | Jan 1, 2019 | 3 min read
2018 closed with hubbub surrounding the purported birth of babies whose genomes had been edited using CRISPR. What will 2019 hold for CRISPR’s use in humans?
Claim of First Gene-Edited Babies Triggers Investigation
Catherine Offord | Nov 26, 2018 | 2 min read
He Jiankui says he has successfully used CRISPR-Cas9 to tweak the genes of twins born earlier this month. Some independent experts are dubious.
pile of powdered cocaine and 3 lines on black surface
Gene-Edited Skin Patch Prevents Cocaine Overdose in Mice
Shawna Williams | Sep 17, 2018 | 4 min read
With a built-in supply of a powerful cocaine-chomping enzyme, the transplant might also curb addiction.
Bioethics Council: Gene-Editing Human Embryos Conditionally OK
Shawna Williams | Jul 17, 2018 | 1 min read
The UK-based organization encourages public debate about the issue but does not recommend immediate policy change.
Electric Shock Allows for CRISPR Gene Editing Without a Viral Vector
Ashley Yeager | Jul 12, 2018 | 2 min read
Brief electroporation appears to make T cells more receptive to new genetic material, which could speed the development of immunotherapies.
CRISPR Trial for Cancer Patients Proposed
Katarina Zimmer | Jan 18, 2018 | 1 min read
US researchers could become the first outside China to use the gene-editing technique in the clinic. 
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