Over-the-Counter Antihistamines Could Help Against Cancer
Over-the-Counter Antihistamines Could Help Against Cancer
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
immune checkpoint blocker
Engineered Bacteria Make Tumors More T Cell-Friendly
Aparna Nathan, PhD | Apr 8, 2022 | 5 min read
Microbes designed to produce specific immunomodulatory metabolites could give immunotherapy a boost.
Uncovering the Cancer Proteome with Automated Western Assays
Bio-Techne | Jan 19, 2022 | 1 min read
A robust, automated western blot system accelerates immunotherapy development.
Multiomic Single Cell CRISPR Screens Reveal Cancer Evasion Mechanisms
10x Genomics | Sep 16, 2021 | 1 min read
Researchers use Perturb-CITE-seq to perform powerful multiomic pooled CRISPR screens.
Infographic: CAR-T Cells in Solid Versus Liquid Cancers
Kerry Grens | Apr 1, 2019 | 2 min read
Tumor accessibility, heterogeneity, and microenvironment vary between the two classes of malignancies.
More Cancer Mutations, Better Immunotherapy Outcomes
Catherine Offord | Jan 15, 2019 | 2 min read
Immune checkpoint inhibitors are generally most effective against tumors with more genetic mutations, according to a new study, although the relationship isn’t true for all cancers.
Fecal Transplant Heals Colitis Caused by Immunotherapy
Anna Azvolinsky | Nov 12, 2018 | 4 min read
A case study of two patients with advanced cancer shows it might be possible to avoid a common and severe side effect of immunotherapy treatment.
Opinion: Learning from Immunotherapy’s Recent Failures
Luis Felipe Campesato | Aug 1, 2018 | 6 min read
The promise of immunotherapy is real. We now need to figure out how to maximize the number of patients the approach benefits.
Immunotherapy More Effective in Men: Study
Kerry Grens | May 18, 2018 | 2 min read
Women with metastatic cancer who were treated with a checkpoint inhibitor had a smaller benefit than did men.
The Cancer Genes Needed for Immunotherapy Response
Anna Azvolinsky | Aug 7, 2017 | 4 min read
Using a large CRISPR-based screen, researchers find possible genetic culprits for patients not having success with immune checkpoint inhibitors.
Gene Mutations Foretell Immunotherapy Response
Aggie Mika | Jun 12, 2017 | 2 min read
A drug that blocks an immune checkpoint protein effectively treats tumors in patients with deficient DNA repair genes.