This month marks the 100-year anniversary of BCG, still the only approved vaccine against the lethal pathogen. But there are new vaccines for this wily foe on the horizon.

Researchers at Imperial College London and the University of Oxford are exposing healthy volunteers to SARS-CoV-2 for science.

Functional profiling of immune cells uncovers targetable mechanisms underlying lung inflammation in severe COVID disease.

By avoiding the production of antibodies, something vaccines ordinarily induce, the immunization sidesteps the problem of antibody-dependent enhancement, which can amplify infection by a similar virus and is known to occur with dengue and Zika.

A study of people in Sierra Leone suggests that the virus can lie in hiding from the immune system before re-emerging later and sparking a new response—although researchers didn’t examine whether this could make people infectious again.

Single-cell proteomics provides novel insights to COVID-19 disease progression

John Connolly and Masataka Nishiga discuss the effects of SARS-CoV-2 on the neurological and cardiovascular systems.

A recent study elucidates some of the changes that occur in the body after inoculation with a tuberculosis vaccine.

Angela Rasmussen and Ya-Chi Ho explore the positive and negative aspects of the host immune response to SARS-CoV-2 infection and discuss how this knowledge influences therapeutic benefits.

The Simple Western automated western blotting platform accelerates characterization of the human IgG immune response to COVID-19.

A meta-analysis of seven randomized controlled trials concludes that dexamethasone and other corticosteroids reduce 28-day mortality in seriously ill patients.

When mice that had suffered a stroke were given blood from a healthy donor, they experienced less tissue and neurological damage.

Increases in the levels of three cytokines are among the features linked to poor outcomes.

The results, while preliminary, suggest that survivors of SARS-CoV-2 infection may be susceptible to reinfection within weeks or months.

Drugs targeting patients’ immune systems, rather than the virus itself, could be key to recovery from severe cases of the disease, some researchers suggest.

By studying influenza in mice and cells, researchers identify a glucose metabolism pathway critical to the dysregulated immune response that kills many infectious disease patients, including those with COVID-19.

In light of recent reports of electronic-cigarette–related illness and death, UNC Chapel Hill professor Robert Tarran discusses the dangerous effects of e-liquids on the lungs.

Neutrophil extracellular traps may hold clues to the cause of skin lesions in patients with a painful condition called hidradenitis suppurativa.

Worms with the reproduction-related TCER-1 gene deleted could fight off infection for longer and survived better when exposed to heat and radiation.